RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
First Semester B. Pharmacy Degree Examination - FirstRanker.com
[Time: 3 Hours] [Max. Marks: 75]
Advanced Medicinal Chemistry
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Q.P. CODE: 5119
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Classify antineoplastic agents with examples. Give the MOA and synthesis of any one antimetabolite drug.
- Explain the significance of prodrugs in drug design and development with specific examples.
- Write a note on enzyme inhibitors in basic research and medicine.
- What do you understand by drug receptor interactions? Explain the theories of receptor interactions.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- What do you understand by drug resistance? Explain its causes.
- Outline the biosynthetic pathway of prostaglandins.
- Write a note on classical and non-classical bioisosteric replacement strategies in analog design of drugs.
- Write a note on COX2 inhibitors. Write the synthesis of any one COX2 inhibitor.
- Explain the MOA and synthesis of any one antiviral drug.
- What are H1 receptor antagonists? Write the MOA and synthesis of any one H1 receptor antagonist.
- Write a note on principles of enzyme inhibitors.
- Outline the design of peptidomimetics by modification of peptide backbone.
- Write a note on solution phase synthesis.
- What do you understand by parallel synthesis in combinatorial chemistry? Explain with examples.
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