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Download RGUHS M.Pharm 2018 May 2nd Year 5179 Principles Of Drug Discovery II Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2018 May (Master of Pharmacy) 2nd Year 5179 Principles Of Drug Discovery II Previous Question Paper

This post was last modified on 11 June 2021

This download link is referred from the post: RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences


Second Semester M. Pharm Examination

[Time: 3 Hours] [Max. Marks: 75]

Principles of Drug Discovery -II

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Q.P. CODE: 5179

Your answers should be specific to the questions asked.

Draw neat, labeled diagrams wherever necessary.

LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks

  1. Explain the prediction of protein structure by threading and homology modeling methods.
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  3. Explain the Free Wilson method with a suitable example.
  4. Explain the factors to be considered in prodrug design with examples.
  5. Discuss any two types of rational drug design methods.

SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks

  1. Discuss the merits and demerits of Hansch and Free Wilson analysis.
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  3. Explain about the role of high throughput screening in rational drug design.
  4. Explain about flexible docking.
  5. Explain In-silico drug design.
  6. What are the applications of NMR and X-ray crystallography in protein structure prediction?
  7. Write a note on 3D-QSAR.
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  9. Explain about role of bioinformatics in target identification and validation.
  10. Explain the role of transgenic animals in target validation.
  11. Explain about role of siRNA’s target identification and validation.
  12. Describe the rationale of prodrug design.

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This download link is referred from the post: RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences

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