RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Examination
[Time: 3 Hours] [Max. Marks: 75]
Principles of Drug Discovery -II
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Q.P. CODE: 5179
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Explain the prediction of protein structure by threading and homology modeling methods.
- Explain the Free Wilson method with a suitable example.
- Explain the factors to be considered in prodrug design with examples.
- Discuss any two types of rational drug design methods.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Discuss the merits and demerits of Hansch and Free Wilson analysis.
- Explain about the role of high throughput screening in rational drug design.
- Explain about flexible docking.
- Explain In-silico drug design.
- What are the applications of NMR and X-ray crystallography in protein structure prediction?
- Write a note on 3D-QSAR.
- Explain about role of bioinformatics in target identification and validation.
- Explain the role of transgenic animals in target validation.
- Explain about role of siRNA’s target identification and validation.
- Describe the rationale of prodrug design.
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