Rajiv Gandhi University of Health Sciences
First Semester M. Pharmacy Degree Examination
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[Time: 3 Hours] [Max. Marks: 75]
Advanced Medicinal Chemistry
Q.P. CODE: 5119
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
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LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Discuss the various stages involved in identification of a lead molecule. Explain the methods of lead optimization and its objectives.
- What are antihypertensive agents? Classify with examples. Write the synthesis and MOA of Propranalol.
- Discuss the modification of various functional groups in the design of prodrugs.
- Explain the rational design of non-covalently and covalently binding enzyme inhibitors with examples.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Explain the different theories of drug-receptor interactions.
- Explain the different strategies to combat drug resistance in anticancer therapy.
- Write a note on design of stereo isomers and geometric isomers with respect to analog design of drugs.
- Classify anticonvulsant agents with examples. Write the MOA and synthesis of Phenobarbitone.
- Write a note on COX1 inhibitors. Write the synthesis of any one COX1 inhibitor.
- Classify antiviral agents with examples. Write the synthesis of zidovidine.
- Explain in detail enzyme inhibitors in basic research with examples.
- What are peptidomimetics? Explain its therapeutic importance.
- Outline the importance of high throughput screening with applications.
- Write a brief note on designing of peptidomimetics.
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