Rajiv Gandhi University of Health Sciences
Degree Examination - March
First Semester
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[Time: 3 Hours] [Max. Marks: 75]
Biopharmaceutics and Pharmacokinetics
Q.P. CODE: 5125
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
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LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Define pharmacokinetics. Explain two compartment models with example.
- Write a note on various approaches to enhance dissolution of poorly soluble drugs.
- Write note on different methods of determining bioavailability.
- Explain various factors affecting drug absorption.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Explain active and passive diffusion of absorption.
- Differentiate in vivo and in vitro methods for the determination of absorption of drugs.
- Write a note on Bioequivalence protocol.
- Explain USP type II dissolution test apparatus.
- Write a note on BCS systems.
- Explain the assumptions and limitations of one compartment model.
- Write the mathematical expressions involved in the determination of pharmacokinetic parameters by feathering method.
- Draw a typical blood level time profiles after oral administration of drug and explain various pharmacokinetic parameters.
- Define non-linear kinetics. Explain the causes of nonlinearity detection.
- Write a note of principles of non linear pharmacokinetics.
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