Rajiv Gandhi University of Health Sciences
First Semester M. Pharmacy Degree Examination
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[Time: 3 Hours] [Max. Marks: 75]
Pharmaceutical Formulation Development
Q.P. CODE: 5109
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
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LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Describe preformulation studies carried out for development of a liquid dosage form.
- Write a model Protocol for physical stability testing process.
- Discuss the importance of IVIVC towards dissolution studies. Explain various techniques of IVIVC.
- What is optimization? Describe briefly about simplex method and factorial design in optimization.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Give a brief overview on additives used in pharmaceutical industry.
- How to design dissolution studies for controlled release formulation?
- Discuss the different methods adopted to evaluate the particle size of a powder.
- Write a note on solution stability.
- Explain micellar solubilization with suitable examples.
- Discuss the methods of drug-excipient compatibility studies.
- Explain characterization of crystals using DSC and XRD.
- Add a note on biorelevant media.
- Discuss the nature of flow properties of pharmaceutical powders.
- Factors influencing intrinsic dissolution studies
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