Download RGUHS M.Pharm 2016 Nov 1st Year 9348 Medicinal Chemistry II Natural Products Revised Scheme 4 Question Paper

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Rajiv Gandhi University of Health Sciences, Karnataka

First Year M. Pharm Degree Examination — NOV 2016

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Time: Three Hours Max. Marks: 100 Marks

MEDICINAL CHEMISTRY-II (Natural Products)

(Revised Scheme 4)

Q.P. CODE: 9348

Your answers should be specific to the questions asked.

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Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 20 = 40 Marks

1. a) Describe in detail the theoretical and practical aspects of microbial conversions.
   b) Enumerate the different reactions possible by microbial conversions. (10+10)
2. a) Describe the significance of structural features, mechanism of action and classification of
   

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   a) Cephalosporins b) Other B lactam antibiotics.
   b) Show how the structure of emetine has been arrived at. (10+10)
3. a) Describe the physiological role of sex hormones. Write their structures. Describe the
   SAR and development of anabolic agents for treatment of infertility.
   b) Classify adrenal cortex hormones; give their therapeutic role. Discuss the structural
   

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   modifications done to obtain useful medicinal agents. (12+8)

SHORT ESSAYS (Answer any FIVE) 5 x 10 = 50 Marks

4. Depict the metabolism of Purines and Pyrimidines.
5. Establish the structure of Morphine.
6. Discuss the chemistry of vitamin B1 with suitable illustrations.

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7. Describe the chemistry and development of B —lactamase stable cephalosporins.
8. Describe the chemistry of carotenoids and discuss the constitution of Vitamin A.
9. Elucidate the structure of Reserpine.

SHORT NOTES 2 x5 = 10 Marks

10. Describe the chemistry and MOA of antiparasitic Purine and Pyrimidine related compounds.

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11. Discuss the biosynthesis and structure of Vitamin D.