Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2015 November (Master of Pharmacy) 1st Year 7891 Modern Pharmaceutical Analysis Os And Rs Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? NOVEMBER 2015
[Time: 3 Hours]
[Max. Marks: 100]
MODERN PHARMACEUTICAL ANALYSIS
(OS & RS)
Q.P. CODE : 7891
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer FOUR questions
LONG ESSAYS (ANSWER ANY FOUR)
4 X 25 = 100 Marks
1.
a) Discuss various ionization techniques in mass spectroscopy and their specific applications.
b) Explain how mass spectroscopy useful in to derive molecular weight and molecular formula
of organic compounds.
c) Write a note on nitrogen rule and ring rule.
2.
a) Explain the theoretical basis of proton NMR spectroscopy. Write in brief about shielding and
deshielding.
b) What is, meant by double resonance in NMR and suitable example?
c) Deduce the structure of the compound using following data:
Mol: formula: C7H8O
IR peaks: 3350 broad, 3050, 2980,1600, 1525, 1450, 1215 cm-1
Mass spectra peak: 108, 107, 91, 77
H-NMR ():3.8 (2H, singlet), 4.3 (1H, singlet), 7.2 (5H, multiplet)
3.
a) Derive Beer's and Lambert's law.
b) Explain different types of electronic transitions observed in the organic molecules.
c) Predict the approximate max for the following compounds and justify your answer (Any two)
4.
Write a note on any FIVE only:
a) Fermi resonance
b) Multicomponent drug analysis
c) FAB mass spectrophotometer
d) Circular dichroism
e) Factors affecting the fluorescence
f) Atomic absorption spectroscopy
5.
a) Write the differences between TLC and HPTLC.
b) Explain the principle of continuous electrophoresis.
c) Write a note on pre column and post column - derivatisation methods in GC and HPLC.
6.
a) Explain, how X-Rays are produced.
b) Write a note on Bragg's law, X-ray powder and rotating crystal method.
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