Rajiv Gandhi University of Health Sciences

First Year M. Pharm Degree Examination - NOVEMBER 2011

[Time: 3 Hours] [Max. Marks: 100]

MODERN PHARMACEUTICAL ANALYSIS (OS & RS)

Q.P. CODE : 7891

Your answers should be specific to the questions asked.

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Draw neat labeled diagrams wherever necessary. Answer FOUR questions

LONG ESSAYS (ANSWER ANY FOUR) 4 X 25 = 100 Marks

1. a) Discuss various ionization techniques in mass spectroscopy and their specific applications.
   b) Explain how mass spectroscopy is useful to derive molecular weight and molecular formula of organic compounds.
   c) Write a note on nitrogen rule and ring rule.
2. a) Explain the theoretical basis of proton NMR spectroscopy. Write in brief about shielding and deshielding.
   

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   b) What is meant by double resonance in NMR with a suitable example?
   c) Deduce the structure of the compound using the following data:
   Mol. formula: C₇H₈O
   IR peaks: 3350 broad, 3050, 2980, 1600, 1525, 1450, 1215 cm^-1
   Mass spectra peak: 108, 107, 91, 77
   

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   ¹H-NMR (d): 3.8 (2H, singlet), 4.3 (1H, singlet), 7.2 (5H, multiplet)
3. a) Derive Beer’s and Lambert’s law.
   b) Explain different types of electronic transitions observed in organic molecules.
   c) Predict the approximate ?_max for the following compounds and justify your answer (Any two)
4. Write a note on any FIVE only:
   

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   a) Fermi resonance
   b) Multicomponent drug analysis
   c) FAB mass spectrophotometer
   d) Circular dichroism
   e) Factors affecting the fluorescence
   

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   f) Atomic absorption spectroscopy
5. a) Write the differences between TLC and HPTLC.
   b) Explain the principle of continuous electrophoresis.
   c) Write a note on pre-column and post-column derivatisation methods in GC and HPLC.
6. a) Explain how X-Rays are produced.
   

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   b) Write a note on Bragg’s law, X-ray powder and rotating crystal method.

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