First Year M.Pharm Degree Examination
[Time: 3 Hours] [Max. Marks: 100]
ADVANCED ORGANIC CHEMISTRY
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(RS 2 & RS 3)
Q.P. CODE: 9202
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
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- a) Discuss the mechanism of different types of rearrangement reactions taking one example each
b) Add a note on resonance theory of Benzene - Write down the mechanism, reaction and synthetic applications for the followings:
a) Friedel - craft reaction
b) Grignard reaction--- Content provided by FirstRanker.com ---
c) Reformatsky reaction
d) Oppeneaur oxidation - a) Give a detailed account of mechanism and stereochemistry of E1 and E2 reaction with particular reference to aliphatic and alicyclic compounds.
b) Add a note on free radical polymerization of alkenes
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- Write a note on concept of retrosynthetic analysis of drugs and its applications
- Write the technique involved in preparing chiral drug. Explain with suitable example
- Give an important synthetic method for preparing pyrimidine. Mention the physiological importance of derivative of pyrimidine
- What are antihistamines? Give the synthesis, medicinal value of any three antihistaminic drugs.
- Write the mechanism of
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a) Backmann rearrangement
b) Wagner-Meerwein rearrangement - Write down synthesis and synthetic utility of malonic ester
SHORT NOTES 2 X5 =10 Marks
- Explain bonding and antibonding
- Explain Jacobsen epoxidation
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