E!E{laaj?a? Eignejmv Isity of Health Sciences
First Year M. Pharm Degree Examination - Oct Nov 2014
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[Time: 3 Hours] [Max. Marks: 100]
ADVANCED PHARMACEUTICAL CHEMISTRY (ORG.)
PAPER II
(Revised Scheme 2)
Q.P. CODE : 9232
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Write an account of formation, stability and reactions of enzyme catalysis in the manufacture of drugs.
- a) Explain about various reactions, which involve nitrenes.
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b) Give the mechanism with examples of Diel’s Alder and Sommelet — Hauser reactions. - a) Discuss different solid-phase methods in combinatorial chemistry.
b) Discuss the various reactive intermediates produced in organic synthesis with one example each.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain about aromatic nucleophilic reactions.
- Give mechanisms of Wolff rearrangement and Cannizzaro reaction.
- Explain phase transfer catalysis in anhydride and ester hydrolysis reactions.
- Explain the applications of macro beads in New Solid Phase synthesis.
- Explain about the Aldol condensation and Cope’s rearrangement by giving examples.
- Write about various applications of Pericyclic reactions.
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SHORT NOTES 2 X 5 = 10 Marks
- Advantages of combinatorial chemistry
- Mechanism of Pinacol-Pinacolone rearrangement
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