Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Oct Nov 2014
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[Time: 3 Hours] [Max. Marks: 100]
MEDICINAL CHEMISTRY - II (NATURAL PRODUCTS)
PAPER IV
(Revised Scheme 2)
Q.P. CODE : 9234
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Discuss the general methods for the isolation of alkaloids. Explain Hoffmann’s exhaustive methylation method and its importance in structural elucidation of alkaloids. Elucidate the structure of Reserpine.
- a) Define glycosides. Classify cardiac glycosides with relevant examples.
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b) Discuss the SAR of cardiac glycosides.
c) Write a note on the sugar moieties attached to cardiac glycosides. - a) Give the degrading and spectroscopic evidence to establish the structure of vincristine.
b) Elucidate the structure of cholesterol.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- Discuss antifungal antibiotics.
- Add a note on Isoprene rule and special Isoprene rule.
- Chemistry of hormone vasopressin and its pharmaceutical importance
- Explain the SAR comparing Digoxin and Ouabain.
- Explain the applications of HPLC and GLC with special reference to plant constituents.
- Outline the synthesis of Cortisone.
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SHORT NOTES 2 X 5 = 10 Marks
- Anti parasitic compounds from purines and pyrimidines
- Explain the chemistry and importance of any two anti diabetic crude drugs.
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