Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Oct Nov 2014
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[Time: 3 Hours] [Max. Marks: 100]
ADVANCED PHARMACOLOGY AND TOXICOLOGY
PAPER II
(Revised Scheme 2)
Q.P. CODE : 9242
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Discuss the structure, mechanism of activation and the targets applicable to GPCR.
- Classify anticancer agents based on their mechanism of actions and discuss the mechanism of each class of drugs. How is the resistance tackled in the cancer chemotherapy?
- Discuss the molecular basis of depression. Explain the mechanism of antidepressant drugs.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain the cellular and molecular level mechanism of actions of insulin and glitazones.
- Discuss the physiology of urine formation. Explain the mechanism of action of diuretics.
- Discuss the mechanism of anti-inflammatory and analgesic action of NSAIDs. Discuss the advantages of COX; selective drugs.
- Discuss the principles of immunosuppression.
- With a brief description of thyroid function, explain the mechanism of action of antithyroid drugs.
- Classify drugs used in the treatment of hypertension. Discuss mechanism of action of any three category of drug.
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SHORT NOTES 2 X5 = 10 Marks
- Factors influencing toxicity
- Reproductive toxicity
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