Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Nov 2023
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[Time: 3 Hours] [Max. Marks: 100]
Advanced Pharmaceutical Chemistry
(Revised Scheme 4)
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
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LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- What are free radicals? Explain the structure, generation, stability and reaction involving free radicals. Add note on protection and deprotection of hydroxyl and amine groups.
- Write in detail with examples of homogenous and heterogenous catalysis.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- What is Benzyne mechanism? Explain the facts supporting the mechanism.
- Give an account of combinatorial chemistry with special reference to parallel organic synthesis.
- Discuss the principle and various techniques in green chemistry.
- Give the mechanism and applications of pinacol-pinacolone rearrangement.
- Discuss the following with relevant examples: - (a) Perkin’s reaction, (b) Benzoin condensation.
- Explain synthon approaches in synthesis of trimethoprim and ciprofloxacin.
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SHORT NOTES 2 X 5 = 10 Marks
- Phase transfer catalysis
- Aldol condensation
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