Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Nov 2023
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[Time: 3 Hours] [Max. Marks: 100]
Medicinal Chemistry — I (Drug Design)
(Revised Scheme 4)
Q.P. CODE: 9347
Your answers should be specific to the questions asked.
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Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain the design concept of any one enzyme inhibitor and classify enzyme inhibitors.
- Write short notes on:
- (a) Receptor-Ligand interaction
- (b) Receptor Binding Assays
- (c) Functional Assays
- (d) Receptor sources.
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- What do you mean by immune response? Explain the drugs affecting immune response.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- How will you explain the relationship between physical properties and biological activity by using Hammet and Taft equations?
- Enumerate and explain computational Protein-Ligand Docking techniques.
- Describe the molecular modeling in drug design using lead optimization.
- Discuss the prodrugs of various functional groups.
- Explain Human growth hormone using t-PA development concept.
- Write a note on drug design and discovery.
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SHORT NOTES 2 X 5 = 10 Marks
- Application of Free-Wilson analysis
- Topological Drug classification
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This download link is referred from the post: RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
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