Download RGUHS M.Pharm 2014 Nov 1st Year 9348 Medicinal Chemistry II Natural Products Revised Scheme 4 Question Paper

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Rajiv Gandhi University of Health Sciences, Karnataka

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First Year M. Pharm Degree Examination - Oct/Nov 2014

Time: Three Hours Max. Marks: 100 Marks

MEDICINAL CHEMISTRY-II (Natural Products)

(Revised Scheme 4)

Q.P. CODE: 9348

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Your answers should be specific to the questions asked.

Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 20 = 40 Marks

1. a) Prove the structure of papaverine based on its chemical degradation and synthesis.
   b) Describe the chemistry and SAR of penicillins along with any one synthesis. (12+8)

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2. a) Describe the chemistry, mechanism of action and classification of steroidal hormones. Add a note on carotenoids and their therapeutic importance
   b) Give proof for the structure of Morphine. (12+8)
3. What are antibiotics? Describe how the B lactamase stable cephalosporins were developed. Add a note on Clavulanic acid analogs.

SHORT ESSAYS (Answer any FIVE) 5 x 10 = 50 Marks

4. Elucidate the structure of Reserpine.

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5. Illustrate the metabolism of Purines and Pyrimidines.
6. Illustrate the various reactions possible by -microbial biotransformations.
7. Elucidate the structure of emetine.
8. Discuss the Purine and Pyrimidine based antineoplastic and antiparasitic agents.
9. Provide evidence for the structure of Vit C.

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SHORT NOTES 2 x5 = 10 Marks

10. Discuss in detail the structure of vincristine and vinblastine.
11. Describe the structural features and development of amido penicillins.