Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2014 November (Master of Pharmacy) 1st Year 9352 Advanced Pharmaceutical Chemistry Revised Scheme 4 Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
First Year M. Pharm Degree Examination ? Oct/Nov 2014
Time: Three Hours

Max. Marks: 100 Marks
ADVANCED PHARMACEUTICAL CHEMISTRY
(Revised Scheme 4)
Q.P. CODE: 9352
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two)
2 x 20 = 40 Marks
1.
With suitable name reactions discuss the mechanism involved in Condensation,
Rearrangement and oxidation-reduction reactions
2.
Discuss in detail the formation, stability, structure of carbenes and Arenas. Add a note on
microwave irradiation techniques with its advantages and limitations
3
Outline the synthetic routes and medicinally important compounds belongs to the following
heterocycles (i) Furan (ii) Benzimidazole (iii) Isoxazole (iv) Phenothiazines and (v) Triazole.
SHORT ESSAYS (Answer any FIVE)
5 x 10 = 50 Marks
4.
With suitable examples explain the mechanism of substitution and addition reactions.
5.
What are Nitrenes? Explain the structure and reactions involving nitrenes.
6.
Discuss the various methods involved in the synthesis of thiophenes and quinoline.
7.
Write an account of the properties of enatiomers. Describe the methods available for
resolution of recemic compounds.
8.
Discuss the preparation and synthetic applications of aceto acetate and Malonic ester.
9.
Explain Geometrical Isomerism and Optical Isomerism with examples.
SHORT NOTES
2 x 5 = 10 Marks
10.
Stereo Chemistry of Steroids.
11.
What do you understand by resonance effect and inductive effect?
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