First Year M. Pharm Degree Examination - Oct
[Time: 3 Hours] [Max. Marks: 100]
INSTRUMENTAL METHODS OF ANALYSIS
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PAPER III
(Revised Scheme 2)
Q.P. CODE : 9223
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
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LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain the principle and a brief procedure in the nitrite titration method and colorimetric method using Bratten Marshal reagent for sulphacetamide and succunyl sulhathiazole.
- Explain the different methods for the determination of solubility and partition coefficient of drugs.
- a) Explain the principle in the quantitative determination of drugs containing ketone and hydroxyl group with suitable examples.
b) Explain the principle and a brief procedure in the assay of Bethmethasone and Fludrocartisone acetate as per IP 1996.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain the principle involved in assay of phenobarbitone using lithium methoxide titrant and principle in the assay of ethosuccimide using tertiary butyl ammonium hydroxide titrant.
- Explain the suitable examples, how the instrumental methods are useful for the product characterization in drug development processes.
- What is particle size analysis? Explain important methods for the same.
- What are the conditions for nephelometry? List the applications of Nephelometry in pharmaceutical analysis.
- How the non-fluorescent drug is converted into fluorescent drug for quantitative estimation? Explain with two examples from different pharmacological class of drug.
- Explain the principle involved in the different methods for the assay of paracetamol. 20 tablets of paracetamol (wt. of 20 tablets - 12.3g),were ground to a powder. Tablet powder of 0.092g (equivalent to 0.075g of paracetamol) was, transferred to a 100ml volumetric flask and the powder was, shaken with 25ml of 0.1M,sodium hydroxide and finally made upto 100 ml with water (solution-A). 10ml of solution-A-was diluted to 100ml with water (solution-B). 10ml of solution-B was, diluted to 100ml with water and the resulting solution gave an absorbance of 0.2416 at 257 nm. Calculate the @amount of paracetamol in each tablet taking 715 as the value of E(1%, 1cm)
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SHORT NOTES 2 X5 = 10 Marks
- Name stationary phase, mobile phase composition, detector used for any two drugs, which are official in IP 1996.
- Why validation is essential for instrumental method of analysis? Explain with suitable examples.
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