RV Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - May 2013
[Time: 3 Hours] [Max. Marks: 100]
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ADVANCED PHARMACEUTICAL CHEMISTRY (ORG.)
PAPER II
(Revised Scheme 2)
Q.P. CODE: 9232
Your answers should be specific to the questions asked.
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Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Write an account of formation, structure and reactions involving carbenes.
- (a) Give the structure and stability of carbocations.
(b) Discuss with suitable examples of Pinacol-Pinacolone and Trans-annular rearrangement. - Explain in detail the various aspects of combinatorial chemistry in drug discovery.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain with various examples of pericyclic reactions.
- Explain the Mechanism of Hofmann and Curtius Schmidt-lossen rearrangement reactions.
- Give an account of phase transfer catalysis in sulfide formation in ester hydrolysis and anhydride.
- Discuss the catalysed reactions in the manufacture of drugs.
- Explain with mechanism of perkin and favorskii rearrangement.
- Give an account of formation, stability and reactions of free radicals.
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SHORT NOTES 2 X5 = 10 Marks
- Give mechanism and reactions of cope rearrangement.
- Discuss the mechanism involved in cannizzaro reaction and Aldol condensation.
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