Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination — May 2013
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[Time: 3 Hours] [Max. Marks: 100]
MEDICINAL CHEMISTRY I (DRUG DESIGN)
PAPER III
(RS 2 & RS 3)
Q.P. CODE: 9233
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- (a) Explain about molecular modeling in drug design.
(b) Write a note on drug receptor interaction. - (a) Explain the merits and de-merits of Hansch and free Wilson analysis.
(b) Discuss in detail about enzyme inhibitors - (a) Discuss the theoretical and practical aspects of Microbial transformation in the production of some steroidal drugs
(b) Give an account on gastric-acid inhibitors.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- What are pro drugs? Explain the various aspects governing pro-drug design
- Give an account of quantum mechanics
- (a) Explain the design of non-covalently binding enzyme inhibitors.
(b) Write a note on the agents under development for HIV infection. - (a) Discuss the design of analogues by bioisosteric replacement.
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(b) Give an appropriate example of the role of recombinant DNA technology in drug discovery. - Explain with suitable examples how partition coefficient and hydrogen bonding affect the biological activity of a drug.
- Discuss in detail the test assays used in testing proton pump inhibitors
SHORT NOTES 2 X5 = 10 Marks
- Add a note on Immuno stimulants with suitable examples
- Add a note on Human growth hormone.
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