Download RGUHS M.Pharm 2012 Nov 1st Year 7922 Medicinal Chemistry I Revised Scheme Question Paper

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Code: 7922

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Draw neat labeled diagrams wherever necessary. Answer FOUR questions

ANSWER ANY FOUR 4 X 25 = 100 Marks

1. 1. Explain the importance of computer graphics in drug design
   2. Write briefly on the role used in genetically engineered drug discovery
   3. Discuss the relative merits and demerits of Hansch analysis and free — Wilson analysis

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2. 1. Discuss the statistical methods employed in QSAR analysis
   2. Write the importance of molecular mechanics in modeling studies
   3. Give an account of High Throughput screening (HTS)

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3. 1. Discuss with examples the various approaches in the design of peptidomimetics
   2. Write briefly on proton pump inhibitors
   3. Discuss the role of ionization constants in drug design
4. 1. Discuss the methods available for the experimental determination of partition coefficient

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   2. Give an account of the intermolecular forces to be taken into account in drug design studies
   3. How is X -ray crystallography useful in drug design
5. Discuss the criteria employed for : -
   1. Receptor mapping
   2. Statistical analysis

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   3. QSAR analysis
6. 1. Give an account of pyrimidine antagonist aimed at pyrimidine targets
   2. Write briefly on the design of antihypertensive quinazolines
   3. What is molecular structure and distance geometry

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Code: 7923

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Draw neat labeled diagrams wherever necessary. Answer FOUR questions

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ANSWER ANY FOUR 4 X 25 = 100 Marks

1. Give a detailed account on serendipitously discovered drug prototypes and their derivatives for the class of drugs you have studied with appropriate example
2. 1. Explain the mechanism of action and chemical modifications in the development of synthetic penicillins over natural penicillins.
   2. Explain the development of B - lactamase stable cephalosporins (15+10)

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3. 1. Explain the general methods employed for determining the structure of alkaloids
   2. Give a detail account on structural elucidation of Morphine based on chemical degradation, synthesis and spectral data (10+15)
4. 1. Give a detailed account on the genetically engineered drug discovery tools with reference to reagents used for screening, enzymes and receptors as drug targets with suitable examples
   2. Give an account of blood glucose regulators (17+8)

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5. 1. What are sex hormones? Give an account on chemistry of natural and currently used synthetic derivatives of male sex hormones.
   2. Explain the development of antifertility agents (15+10)
6. Give detail account on protein engineering and site directed mutagenesis and explain the usefulness of these techniques in discovery of new therapeutics

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Code: 7924

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Draw neat labeled diagrams wherever necessary. Answer FOUR questions

ANSWER ANY FOUR 4 X 25 = 100 Marks

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1. 1. Give an account of the steriochemical considerations to be taken into account in the determination of reaction mechanisms
   2. Discuss with examples the relative acidities of aliphatic and aromatic carboxylic acids and phenols
2. Write briefly on:
   1. Transannular rearrangements
   2. Cannizaro reaction

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   3. 1, 4 and 1, 2 addition
   4. Benzoin condensation
3. Give an account of the substitution reactions and discuss the evidence in favour of these reactions
4. Give a account of
   1. Aromatic nuclephiic substitution

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   2. Wolff rearrangement
   3. Beckmann rearrangement
   4. Pinacol - pinacolone rearrangement
5. 1. What is homoeopathic and heterogeneous catalysis and write its importance

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   2. Discuss the photochemistry of butadienes
   3. What are cyclo addition reactions
6. Write short note on:
   1. Electrocyclic reaction
   2. Reduction reaction

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   3. Conformation analysis
   4. Resolution of racemic mixtures

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