Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2012 November (Master of Pharmacy) 1st Year 7942 Clinical Pharmacology And Toxicology Revised Scheme Previous Question Paper

7942_2012_2_S151
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
CLINICAL PHARMACOLOGY and TOXICOLOGY
(Revised Scheme)
Q.P. CODE : 7942
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer FOUR questions
ANSWER ANY FOUR
4 X 25 = 100 Marks
1.
(a) Explain Neurohumoral transmission of autonomic nervous system.
(b) Classify adrenergic agonists and Antagonists and explain Mechanism of action, toxicity of
one drug from each category.
2.
Classify immunosuppressants. Discuss role of immunosuppressants in the solid organ
transplantation.
3.
(a) Write the general principles of chemotherapy. Write the mechanism of action, toxicities of
drugs use in UTI.
(b) General principles and management of acute poisoning.
4.
(a) Give Vaughan Williams classification for antiarrythmic drugs. Explain the pharmacology of
one drug from each class.
(b) Pharmacology of drugs used in Brady arrhythmias.
5.
What are local hormones? Explain the synthesis, storage, metabolism, receptors and role of
Histamine in the body, and add a note on H1 receptor antagonists.
6.
(a) Classify different types of Diabetes. Discuss briefly pathophysiology of Diabetes.
(b) Classify anti-diabetic drugs and explain the detail mechanism of action, adverse reactions
and uses of any one drug from each class.
* * * * *

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7943_2012_2_S156
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
PHARMACOLOGICAL SCREENING METHODS AND
CLINICAL EVALUATION
(Revised Scheme)
Q.P. CODE: 7943
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer FOUR questions
ANSWER ANY FOUR
4 X 25 = 100 Marks
1.
(a) What is biotransformation? Describe Type-II biotransformation reactions.
(b) Explain the role of enzyme induction in drug response.
2.
(a) Discuss various methods of screening antiepileptic agents.
(b) Discuss the methods of screening CNS stimulants.
3.
(a) What is bioassay? Explain the bioassay of oxytocin.
(b) Classify various types of immunoassays. Explain the principle and applications of
raioimmuno assay in drug research.
4.
(a) Discuss the various phases of clinical trials.
(b) Discuss various methods of assessing the toxicity of a drug.
5.
Give a note on:
(a) Essential drug list (WHO).
(b) Orphan drugs.
(c) Wilcoxon tests.
(d) Bioavailability.
(e) Rational drug concept.
6.
(a) What is transgenic animals and how they differ from normal animals? Explain the
importance of transgenic animals in experimental pharmacology.
(b) What is student`t' test? Explain its application in pharmacological studies.
* * * * *

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7944_2012_2_S156
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
RECENT ADVANCES IN PHARMOCOLOGY

(Revised Scheme)
Q.P. CODE: 7944
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer FOUR questions
ANSWER ANY FOUR
4 X 25 = 100 Marks
1.
(a) Discuss the pathogenesis, risk factors and pharmacotherapy of essential hypertension.
(b) Discuss the pathophysiology and pharmacotherapy of Constipation and Diarrhoea.
2.
(a) Rational approaches of the Pharmacotherapy of Constipation and Diarrhoea.
(b) Discuss the management of chronic renal failure.
3.
(a) Discuss the pathophysiology of different types of epileptic disorders and their specific
pharmacotherapy.
(b) Discuss the drug therapy of COPD.
4.
(a) Discuss the pharmacotherapy of Osteoporosis.
(b) Describe the pathogenesis of glaucoma and discuss the principles of drug therapy.
5.
(a) With a note on the pathophysiology of pain perception, discuss the pharmacotherapy of
pain management.
(b) Describe the pharmacotherapy of actute lymphocytic leukaemia.
6.
(a) Discuss the multidrug therapeutic regimens in the management of AIDS.
(b) Drug resistant malaria and its treatment.
* * * * *

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• 7942_2012_2_S151.doc
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• 7943_2012_2_S156.doc
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• 7944_2012_2_S156.doc
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