Q.P. CODE: 9201
Your answers should be specific to the questions asked.
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Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Write about basic principle and instrumentation in mass spectrometry. Write in detail about different types of ionizer used in mass spectroscopy. Comment on time of flight analyses.
- Define chemical shift outline with a neat sketch about NMR instrumentation. Explain about FT-NMR
- What are the different types of columns used in HPLC. Explain HPTLc
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Write in detail about double beam UV spectroscopy
- Explain construction and working of different types of detectors in IR spectrometers
- Write mass fragmentation patterns and Pmr spectral features for Benzyl Benzoate
- Write factors affecting migration of ions in electrophoresis
- State bragg's law. Explain the application of X - ray diffraction
- Explain the theory and application of GC
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SHORT NOTES 2 X 5 = 10 Marks
- Test of significance
- Thesis writing
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Q.P. CODE: 9202
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- a) Write in detail about Inductive effect with its applications
b) Distinguish between SN1 and SN2 reaction in all aspects with reaction mechanism - a) Define catalysis. Explain the importance of homogenous catalysis in the manufacture of drugs
b) Write the phase transfer catalysis in epoxide formation from aldehyde - Write the mechanism and synthetic applications for the followings:
a) Oppenauer oxidation
b) Claisen condensation
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Give the synthesis and an example of medicinal molecule belonging to the following heterocyclic ring system
a) Morpholine (b) Phenothiazine (c) Thiazoles (d) Benzthiadiazole - Add a note on resolution of racemic modifications
- Formulate the reaction of hydrogen bromide with propane both in absence and in presence of peroxides. Justify the formation of the products in each case
- Write the mechanism and any two synthetic applications of active methylene groups
- How tetrazole is prepared? Name two drugs with structures possessing purine ring and indicate their therapeutic use
- Add a note on carbonium ions as reactive intermediates
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SHORT NOTES 2 X 5 = 10 Marks
- Enzymatic separation
- Intra molecular nucleophillic attack in chiral drugs
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Q.P. CODE: 9203
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- a) Name the drugs produced by semi synthetic method with examples
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b) Describe the Fermentation process for the production of a drug
c) Explain the Tissue culture technique with example - a) Explain in detail the capital venture
b) Describe the plant design, layout and Construction of a Bulk drug plant - a) Explain the terms “Loan License" and "Repacking on Demand" and the requirements to get the license
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b) Give the structure of National Drug authority and describe it functions.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Add note on Import and Export policies for Bulk drugs
- Explain the concept of Multipurpose Bulk drug production plant
- Describe the safe operating procedures of the chemical plant
- Write the flow sheet and reaction sequences for the production of Diazepam
- Write the reaction flow diagram and production of Metaprolol
- Explain the commercial production of Vincristine
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SHORT NOTES 2 X 5 = 10 Marks
- Explain the term "Exim policy"
- Write a short note on "Combinatorial chemistry"
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Q.P. CODE: 9204
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- a) How do you handle the complaints received? Detail its evolution and discuss the rectification,
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b) Quality audit of manufacturing plant
c) Discuss the phases of certification of ISO 9000 series. - Explain in detail about the responsibilities and work discipline of the personnel working in an industry. Illustrate with a neat diagram the layout of a bulk drug plant.
- Explain in detail about the importance of validation in a pharmaceutical industry. Briefly describe the purpose of documentation to get US FDA approval.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- Describe requirements for animal testing facility
- What are the differences present between FDA guidelines and schedule M proposed by Govt. of India?
- Explain about Good ware housing practice.
- Briefly explain the following
a) Patent act b) Monopoly restriction act. - Explain about the application of computer in GMP and GLP.
- What is statutory certificate of suitability? Explain the trade mark act.
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SHORT NOTES 2 X 5 = 10 Marks
- Write short notes on auditing.
- Briefly describe about ISO 9000-9004 certifications
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