Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2012 November (Master of Pharmacy) 1st Year 9201 Modern Pharmaceutical Analysis Rs 2 And Rs 3 Previous Question Paper

9201_2012_2_S201
Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination ? Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
MODERN PHARMACEUTICAL ANALYSIS
(RS 2 & RS 3)

Q.P. CODE: 9201
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
Write about basic principle and instrumentation in mass spectrometry. Write in detail about
different types of ionizer used in mass spectrsopy. Comment on time of flight analyzes.
2.
Define chemical shift outline with a neat sketch about NMR instrumentation. Explain about FT-
NMR
3.
What are the different types of columns used in HPLC. Explain HPTLc
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Write in detail about double beam UV spectroscopy
5.
Explain construction and working of different types of detectors in IR spectrometers
6.
Write mass fragmentation patterns and Pmr spectral features for Benzyl Benzoate
7.
Write factors affecting migration of ions in electrophoresis
8.
State bragg's law. Explain the application of X ? ray diffraction
9.
Explain the theory and application of GC
SHORT NOTES
2 X 5 = 10 Marks
10. Test of significance
11. Thesis writing
* * * * *

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9202_2012_2_S272
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
ADVANCED ORGANIC CHEMISTRY
(RS 2 & RS 3)

Q.P. CODE: 9202
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
a) Write in detail about Inductive effect with its applications
b) Distinguish between SN1 and SN2 reaction in all aspects with reaction mechanism
2.
a) Define catalysis. Explain the importance of homogenous catalysis in the manufacture of
drugs
b) Write the phase transfer catalysis in epoxide formation from aldehyde
3.
Write the mechanism and synthetic applications for the followings:
a) Oppenauer oxidation
b) Claisen condensation
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Give the synthesis and an example of medicinal molecule belonging to the following
heterocyclic ring system
a) Morpholine (b) Phenothiazine (c) Thiazoles (d) Benzthiadiazole
5.
Add a note on resolution of racemic modifications
6.
Formulate the reaction of hydrogen bromide with propane both in absence and in presence of
peroxides. Justify the formation of the products in each case
7.
Write the mechanism and any two synthetic applications of active methylene groups
8.
How tetrazole is prepared? Name two drugs with structures possessing purine ring and indicate
their therapeutic use
9.
Add a note on carbonium ions as reactive intermediates
SHORT NOTES
2 X 5 = 10 Marks
10. Enzymatic separation
11. Intra molecular nucleophillic attack in chiral drugs
* * * * *

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9203_2012_2_S281
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
BULK DRUG TECHNOLOGY
(RS 2 & RS 3)

Q.P. CODE: 9203
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
a) Name the drugs produced by semi synthetic method with examples
b) Describe the Fermentation process for the production of a drug
c) Explain the Tissue culture technique with example
2.
a) Explain in detail the capital venture
b) Describe the plant design, layout and Construction of a Bulk drug plant
3.
a) Explain the terms "Loan License" and "Repacking on Demand" and the requirements to get
the license
b) Give the structure of National Drug authority and describe it functions.
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Add note on Import and Export policies for Bulk drugs
5.
Explain the concept of Multipurpose Bulk drug production plant
6.
Describe the safe operating procedures of the chemical plant
7.
Write the flow sheet and reaction sequences for the production of Diazepam
8.
Write the reaction flow diagram and production of Metaprolol
9. Explain
the
commercial
production of Vincristine
SHORT NOTES
2 X 5 = 10 Marks
10. Explain the term "Exim policy"
11. Write a short note on "Combinatorial chemistry"
* * * * *

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9204_2012_2_S203
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
GOOD MANUFACTURING AND LABORATORY PRACTICE
(RS 2 & RS 3)

Q.P. CODE: 9204
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
a) How do you handle the complaints received? Detail its evolution and discuss the rectification,
b) Quality audit of manufacturing plant
c) Discuss the phases of certification of ISO 9000 series.
2.
Explain in detail about the responsibilities and work discipline of the personnel working in an
industry. Illustrate with a neat diagram the layout of a bulk drug plant.
3.
Explain in detail about the importance of validation in a pharmaceutical industry. Briefly
describe the purpose of documentation to get US FDA approval.
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Describe requirements for animal testing facility
5.
What are the differences present between FDA guidelines and schedule M proposed by Govt. of
India?
6.
Explain about Good ware housing practice.
7.
Briefly explain the following
a) Patent act b) Monopoly restriction act.
8.
Explain about the application of computer in GMP and GLP.
9.
What is statutory certificate of suitability? Explain the trade mark act.
SHORT NOTES
2 X 5 = 10 Marks
10. Write short notes on auditing.
11. Briefly describe about ISO 9000-9004 certifications
* * * * *

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Document Outline

• 9201_2012_2_S201.doc
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• 9202_2012_2_S272.doc
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• 9203_2012_2_S281.doc
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• 9204_2012_2_S203.doc
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