(RS 2 & RS 3)
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Q.P. CODE: 9233
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Discuss in detail about various parameters employed in QSAR studies.
- (a) Classify immuno suppressants and immuno stimulants in detail.
(b) Explain the design of non covalently binding enzyme inhibitors. - (a) WHAT are pro drugs? Explain the various aspects governing Pro-drug design.
(b) Give an account of irreversible gastric-proton pump inhibitors.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- Briefly discuss the theoretical and practical aspects of microbial transformation.
- Describe the molecular modeling in drug design.
- Briefly describe about recombinant DNA technology.
- Write about the importance of Bio-isosterism and steric features in drug design.
- Describe in detail about epitope mapping and HIV – TAT inhibitor
- Give the application of Hansch and free Wilson analysis in QSAR studies.
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SHORT NOTES 2 X 5 = 10 Marks
- Describe the mechanism of Gastric Acid secretion and inhibition
- Explain any one method for the calculation of partition co-efficient.
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Q.P. CODE: 9234
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
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- Elucidate the structure of Reserpine.
- Classify adrenal cortex hormones and give SAR and synthesis of Hydrocortisone.
- What are the limitations of insulin therapy? How insulin is prepared, stored and released into blood stream
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain the metabolism of purine and pyrimidines
- Explain nocardins and carbapenams as antibiotics?
- Write a note on synthetic estrogens
- Explain the biosynthetic pathway of male sex hormone
- Discuss anti-pseudomonal penicillin
- Explain the different classes of anticancer agents
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SHORT NOTES 2 X 5 = 10 Marks
- Explain the active constituents and uses of Gymneme sylvestere
- Write the structure and mechanism of action of two antifungal agents
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