Download RGUHS M.Pharm 2012 Nov 1st Year 9242 Advanced Pharmacology And Toxicology Paper II Rs 2 And Rs 3 Question Paper

Your answers should be specific to the questions asked.

Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

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1. Define receptor. Describe G protein coupled receptor and their role in signal transduction with an example using a neat diagram
2. Classify antiarrhythmic drugs. Give an account of pharmacology and adverse reactions of quinidine
3. Classify analgesics with examples. Discuss the pharmacology of Cox-1 and Cox-2 inhibitors

SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. Cardio selective sympathomimetics

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5. Cardiotonics
6. Carcinogenicity
7. Oral hypoglycemic agents
8. Anti protozoals
9. Management of parkinsonism

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SHORT NOTES 2 X 5 = 10 Marks

10. Anti - diuretics
11. Diazepam

Your answers should be specific to the questions asked.

Draw neat labeled diagrams wherever necessary. Answer all questions

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LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

1. Give the clinical study design documentation, presentation and interpretation of clinical trails as per ICMR - GCP guidelines.
2. a) Explain the rationale of different screening methods for anti – hypertensive drugs
   b) Explain any two methods used to screen antihypertensive agents.
3. a) Describe experimental models and statistical designs employed in biological standardization.
   

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   b) Describe the bioassay of ACTH

SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. Alternatives to animal screening procedures
5. Nonlinear pharmacokinetics
6. Screening of anti - malarials

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7. Physiological models for drug development.
8. Drug transport mechanisms in absorption.
9. Explain the factors to be considered during drug individualization

SHORT NOTES 2 X 5 = 10 Marks

10. Molecular biology techniques

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11. Newer techniques of drug administration.

Your answers should be specific to the questions asked.

Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

1. Discuss the structure and function of various organelles of mammalian cell with a neat labeled diagram. Explain the various phases of cell cycle

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2. Describe the various steps involved in the production of a recombinant protein using recombinant technology with neat labeled diagrams
3. Discuss the structure of DNA with a neat labeled diagram. Explain the factors that control the gene expression

SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. Apoptosis
5. Culture and maintenance of mammalian cells

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6. DNA sequencing
7. Viral vectors
8. Monoclonal antibodies in therapy
9. Recombinant Hormones

SHORT NOTES 2 X 5 = 10 Marks

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10. Anti sense technology
11. Biosensor

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