Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2012 November (Master of Pharmacy) 1st Year 9242 Advanced Pharmacology And Toxicology Paper II Rs 2 And Rs 3 Previous Question Paper

9242_2012_2_S272
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
ADVANCED PHARMACOLOGY AND TOXICOLOGY
PAPER II


(RS 2 & RS 3)

Q.P. CODE: 9242
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
Define receptor. Describe G protein coupled receptor and their role in signal transduction with
an example using a neat diagram
2.
Classify antiarrhythmic drugs. Give an account of pharmacology and adverse reactions of
quinidine
3.
Classify analgesics with examples. Discuss the pharmacology of Cox-1 and Cox-2 inhibitors
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Cardio selective sympathomimetics
5. Cardiotonics
6. Carcinogenecity
7.
Oral hypoglycemic agents
8.
Anti protozoals
9.
Management of parkinsonism
SHORT NOTES
2 X 5 = 10 Marks
10. Anti ? diuretics
11. Diazepam
* * * * *

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9243_2012_2_S206
Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination ? Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
PHARMACOLOGICAL SCREENING METHODS
AND CLINICAL EVALUATION
PAPER III


(RS 2 & RS 3)

Q.P. CODE: 9243
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
Give the clinical study design documentation, presentation and interpretation of clinical trails as
per ICMR ? GCP guidelines.
2.
a) explain the rationale of different screening methods for anti ? hypertensive drugs
b) Explain any two methods used to screen antihypertensive agents.
3.
a) Describe experimental models and statistical designs employed in biological standardization.
b) Describe the bioassay of ACTH
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Alternatives to animal screening procedures
5. Nonlinear
pharmacokinetics
6.
Screening of anti ? malarials
7.
Physiological models for drug development.
8.
Drug transport mechanisms in absorption.
9.
Explain the factors to be considered during drug individualization
SHORT NOTES
2 X 5 = 10 Marks
10. Molecular blology techniques
11. Newer techniques of drug administration.
* * * * *

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9244_2012_2_S272
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? Nov 2012

[Time: 3 Hours]
[Max. Marks: 100]
MOLECULAR BIOLOGY
PAPER IV


(RS 2 & RS 3)

Q.P. CODE: 9244
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
Discuss the structure and function of various organelles of mammalian cell with a neat labeled
diagram. Explain the various phases of cell cycle
2.
Describe the various steps involved in the production of a recombinant protein using
recombinant technology with neat labeled diagrams
3.
Discuss the structure of DNA with a neat labeled diagram. Explain the factors that control the
gene expression
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4. Apoptosis
5.
Culture and maintenance of mammalian cells
6. DNA
sequencing
7.
Viral vectors
8. Monoclonal
antibodies in therapy
9.
Recombinant Hormones
SHORT NOTES
2 X 5 = 10 Marks
10. Anti sense technology
11. Biosensor
* * * * *

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• 9242_2012_2_S272.doc
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• 9243_2012_2_S206.doc
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• 9244_2012_2_S272.doc
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