Download RGUHS M.Pharm 2010 Oct 2010 Oct 7923 Medicinal Chemistry II Revised Scheme Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2010 October (Master of Pharmacy) 2010 Oct 7923 Medicinal Chemistry II Revised Scheme Previous Question Paper

7923_2010_2_S206.doc
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - October 2010

[Time: 3 Hours]
[Max. Marks: 100]
MEDICINAL CHEMISTRY - II

(Revised Scheme)
Q.P. CODE : 7923
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer FOUR questions
ANSWER ANY FOUR
4 X 25 = 100 Marks
1.
a) Enlist the sources of drugs giving suitable examples.. How are the drugs discovered through
serendipity
b) Discuss in detail about early cephalosporins and amido penicillins
2.
a) How are prostaglandins biosynthesized and disposed off from the body
b) What are lactam antibiotics? Add an note on the development of semi synthetic penicillins
c) Enlist the hormones secreted from adrenal cortex. Add a note on neurohormones
3.
a) Give the mechanisms of action of positive ionotropic agents. Explain the structures features
of cardiac glycosies
b) what is passive ? ion transport and explain its utility medicine
c) Add a note on plant products as antitumor drugs
4. a) Discuss the structure elucidation of Reserpine
b) Give an account of diabetes mellitus and the use of insulin preparations
5.
a) What is recombinant DNA technology? Explain the term protein engineering and site
directed mutagenesis
b) Discuss the effects of Anti ? anxiety agents and alkylating agents during toxicological
experiments
6. Write short notes on"
a) Carbapenams & Monolactams
b) Chemistry of emetine
c) Crude drugs in diabetes therapy
d) Salicin
e) Enzymes as drug targets
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