Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2010 October (Master of Pharmacy) 2010 Oct 9232 Advanced Pharmaceutical Chemistry Org. Paper II Revised Scheme 2 Previous Question Paper
Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - October 2010
[Time: 3 Hours]
[Max. Marks: 100]
ADVANCED PHARMACEUTICAL CHEMISTRY (ORG.)
PAPER II
(Revised Scheme 2)
Q.P. CODE : 9232
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
a) Explain in detail with mechanism about pinacol-pinacolone rearrangement.
b) what do you mean by cine substitution? Discuss the mechanism involved with suitable
examples.
2.
a) Define free radical. Explain in detail the formation of free radical. Explain in detail reaction
involving free radicals.
b) Discuss the mechanism involved in Benzoin condensation and perkin reaction.
3.
a) Give an account of ring expansion with appropriate examples
b) Discuss the Mechanism of Hoffmann rearrangement with suitable examples.
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Write about trans ? annular rearrangements with suitable examples.
5.
What are nitrenes? Discuss the mechanism involved in curtius reaction schmdt & lossen
rearrangement.
6.
Discuss the principle involved in phase transfer catalysis with appropriate example
7.
What do you mean by sigmatropic rearrangement the synthetic applications of sigmatropic
rearrangement.
8.
Discuss the mechanism involved diels ? alder reaction using molecular orbital method
9.
Write a note on combinatorial chemistry
SHORT NOTES
2 X 5 = 10 Marks
10. Discuss the formation structure and stability of Carbocations.
11. Free radicals.
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