Download RGUHS M.Pharm 2010 Oct 2010 Oct 7943 Pharmacological Screening Methods And Clinical Evaluation Revised Scheme Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2010 October (Master of Pharmacy) 2010 Oct 7943 Pharmacological Screening Methods And Clinical Evaluation Revised Scheme Previous Question Paper

7943_2008_1_S157.doc
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? October 2010

[Time: 3 Hours]
[Max. Marks: 100]
PHARMACOLOGICAL SCREENING METHODS AND
CLINICAL EVALUATION
(Revised Scheme)
Q.P. CODE : 7943
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer FOUR questions
ANSWER ANY FOUR
4 X 25 = 100 Marks
1.
(a) New drug for AIDS has been discovered. Describe the procedures involved in IND and NDA
submissions for the same.
(b) Discuss various types of drug interactions with examples.
2.
(a) Describe in detail the study of acute and sub acute toxicity of a new drug.
(b) Explain the principles involved in RIA.
3.
(a) Define bio-availability, describe the various parameters measured in bio-availability studies
with their therapeutic importance.
(b) Discuss in brief, the four main types of receptor-mediated drug action with examples.
4.
Describe the major pre-clinical screening procedures for the following:
(a) Drugs for peptic ulcers.
(b) Drugs for Parkinsonism.
(c) Local anaesthetics.
5.
(a) Explain the factors that modify drug pharmacokinetics.
(b) Why are bioassays preferred to other methods of assays? What are the difficulties faced in
standardization of bioassays? Illustrate the principles of bioassays with the help of some
examples.
6.
Write short notes on any Five of the following:
(a) Non Parametric test.
(b) Transgenic animals.
(c) Application of student's t-test.
(d) Measures of variability.
(e) MES Method.
(f) Adverse drug reaction.
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