RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
(Revised Scheme 2)
Q.P. CODE : 9233
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- What is protein engineering and site directed mutagenesis? Explain their use in development of therapeutic agent.
- Explain the following with examples.
- bioisosteric replacement
- homologation of alkyl chain
- Rigid analogs (8+6+6)
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- Write importance of ACE inhibitor. Explain Chemistry of ACE along with SAR of ACE inhibitors.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- Enlist various micro organisms used as a biocatalyst. Explain use of biocatalyst in preparation of Drugs with suitable examples.
- Enlist various methods for calculation of partition coefficient. Explain any one.
- Classify proton pump inhibitors. Write SAR, use and side effects of omeprazole as proton pump inhibitors.
- What are immunosuppressive agents? Explain their need as a therapeutic agent with suitable examples?
- How will you develop HIV-tat inhibitor using recombinant DNA techniques? Justify the answer with suitable examples.
- Explain various therapeutic aspects of microbial transformation.
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SHORT NOTES 2 X 5 = 10 Marks
- Prodrug design.
- Free Wilson Analysis.
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