Download RGUHS M.Pharm 2010 May 1st Year 9233 Medicinal Chemistry I Drug Design Paper IIi Revised Scheme 2 Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2010 May (Master of Pharmacy) 1st Year 9233 Medicinal Chemistry I Drug Design Paper IIi Revised Scheme 2 Previous Question Paper

9233_2009_1_S151.doc
Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination ? May - 2010

[Time: 3 Hours]
[Max. Marks: 100]
MEDICINAL CHEMISTRY I (DRUG DESIGN)
PAPER III
(Revised Scheme 2)

Q.P. CODE : 9233
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
What is protein engineering and site directed mutagenesis? Explain their use in development of
therapeutic agent.
2.
Explain the following with examples.
a) bioisosteric replacement b) homologation of alkyl chain c) Rigid analogs (8+6+6)
3.
Write importance of ACE inhibitor. Explain Chemistry of ACE along with SAR of ACE inhibitors.
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Enlist various micro organisms used as a biocatalyst. Explain use of biocatalyst in preparati0on
of Drugs with suitable examples.
5.
Enlist various methods for calculation of partition coefficient. Explain any one.
6.
Classify proton pump inhibitors. Write SAR, use and side effects of omeprazole as proton pump
inhibitors.
7.
What are immunosuppressive agents? Explain their need as a therapeutic agent with suitable
examples?
8.
How will you develop HIV-tat inhibitor using recombinant DNA techniques? Justify the answer
with suitable examples.
9.
Explain various therapeutic aspects of microbial transformation.
SHORT NOTES
2 X 5 = 10 Marks
10. Prodrug
design.
11. Free Wilson Analysis.
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