RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
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- Deduce equations to obtain pharmacokinetic parameters of a drug administered by oral route, the drug undergoing absorption by first order kinetics and body acting as a single compartment
- Explain Michaelis-Menten equation and estimation of Km and Vmax
- Explain in detail the application of pharmacokinetics in new drug development and designing of dosage forms
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Biological factors affecting absorption of drugs
- Write a note on therapeutic drug monitoring
- Explain with examples conjugation reactions for elimination of drugs
- Write on adjustment of dosage in renal and hepatic impairment
- Write on objectives and considerations in bioavailability study
- Explain significance and kinetics of protein binding
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SHORT NOTES 2 X5 = 10 Marks
- Concept of loading and maintenance dose
- Volume of distribution
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