RBC INDICES
e.g 1 unit of blood is taken
Anticoagulate it & then centrifuge it.
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It will have 0.45 cell.
this is PCU
PCV (Hematocrit)
The Volume of blood occupied by Packed RBC.
Red Cell Count:
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No of RBC in Unit of blood
In healthy Person
1ml = 5 Million RBC
100ml. 500 Million RBC
Eg
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In both cases Hematocrit is Equal.
but RBC Count is
Dess in Macrocytic & more in case of Microcytic
RBC Count's Equal in both cases but PCV is diff
Hb Concentration: Conc of Hb in 100 ml of blood Normal.
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RBC is boring of Hb but not 100% full.
1/3rd of them are loaded with Hb.
blk this is the total metabolic capacity of given cells to made Hb
Conc of Hb per 100ml of blood.
100ml blood = 4.5 ml RBC
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& 1/3 of RBC is Hb
45 - 15
loomla have = 15% of Hb
or 15 g/dl
It is not Necessary that 2 pts con have RBC Count & Hematocrit Save also have same Hb Conc
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bc It depends of Heamoglobinization of Cells.
Mean Corpuscular Volume (MCV)
Mean Volume of one RBC.
Mean Corpuscular Hb Concentration (MCH)
Amount of Hb in each RBC
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Mean Corpuscular Hb Conc (MCHC)
Concentration of Hb in each R.B.C
M.C.V= P.C.U = 0.45 = 90x10-15 L
Red Cell Count 500,000
M.C.V = 90 Femto L
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M.C.H = Total Hb = 15 =30Pgm
Red cell Count 500,000
M.C.H = 30 pgm
MCHC = Total Hb = 15 = 33%
Total vol 0.45
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MCHC = 33%
Normally In RBC Hb is more at Pheriphery and les in the center so center is pale. (1/3rd of cell is Pales
Such looks red, Normochromic
In this cell Size/volume also normal. So It is Normocytic & Normochromic
(i.e MCV & MCHC is Normal)
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Microcytic MCV<80fL Normal MCV=90±10fL MCV > 100fl
Microcytic Normochromic Normochromic Macrocytic
& MCV = 90fg Normochromic
MCV = 60fL Normo MCH 30pg
MCH = 20pg Chromic MCHC 33%
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MCHC = 33% Normocytic
Microcytic & MCV = 90fg MCV = 120
Hypochromic hypo MCH = 20 pg MCH 40
Chromic MCHC= 22% MCHC 33
MCV = 60 Normocytic
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MCH = 15pg & MCV=90fg Macrocytic
MCHC = 25% hyper MCH = 45 pg Hypochromic
Microcytic Chromic MCHC = 50%
Hypochromic
MCV = 90 ? 60fL (due to spherocytosis)
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MCH = 30pgm (remains save)
MCHC = 50% (Red)
Spherocytosis:-
RBC membrome was lot while they are passing through Narrow Capillaries.
Red Cell Distribution Width: R.D.W
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There is vanation acording to Size of cells.
Normal Distribution Curve is bell shaped
MCV=90
All RBC are of Save Size
MC V= 90
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Width of Distribution Curve is less
Width of Distribution is Wide.
An Isocytosis
i.e
Cells are of not equal Size
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Width of Distribution Curve is more.
(e.g aperson is Microcytic & injected with Normocytic blood now he has two type of cells).
Been in pt with double Anemia..
eig pt have
Iron def Anemia + B12 def Anemia
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Iron def A (RBC? microcytics
B12 def A (RBC Macrocytic)
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This download link is referred from the post: MBBS Lecture Notes for all subjects (updated for 2021 syllabus) - All universities