Rajiv Gandhi University of Health Sciences, Karnataka
I Year B. Pharm Degree Examination — 30-Oct-2024
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Time: Three Hours Max. Marks: 70
PHARMACEUTICAL ORGANIC CHEMISTRY - I (RS-4)
Q.P. CODE: 2628
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- a) Write the mechanism and stereochemistry of SN2 and SN1 reactions
b) Explain the kinetics and mechanism of E2 reaction - a) Explain electrophilic aromatic substitution reaction. Write the mechanism of sulphonation in benzene
b) Write the mechanism of cycloaddition reaction with example - a) How naphthalene is prepared by Haworth’s synthesis and give it’s chemical properties
b) Write any three methods of preparation of cycloalkanes
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Define isomerism. Write the classification of structural isomerism with suitable example
- Explain dehydration of alcohol with suitable example
- Discuss Aldol condensation with mechanism
- Discuss the effect of substituents on basicity of aliphatic and aromatic amines
- What is diazotization and give its mechanism?
- Discuss Claisen condensation reaction with mechanism
- Write conversion of carboxylic acid into acid chloride, ester and amide
- Write a note on activating and de-activating groups with suitable example
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SHORT ANSWERS 10 x 2 = 20 Marks
- Define Alkane and Alkenes with example
- Write the structures of anthracene and acetone
- What is mesomeric effect?
- What are nucleophiles and leaving groups?
- Define Saytzeff’s rule
- Write the IUPAC names of a) Isobutane b) Ethylmethyl ketone
- What are amines and why they are basic in nature?
- Define Kolbe’s reaction?
- What is E1 and E2 reaction?
- Why choloroacetic acid is more acidic than acetic acid
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