Rajiv Gandhi University of Health Sciences, Karnataka
I Year B. Pharm Degree Examination — 10-Jan-2020
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Time: Three Hours Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY - I (RS - 4)
Q.P. CODE: 2628
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- a) Discuss the mechanism and stereochemistry of SN1 reaction.
b) Explain the kinetics and mechanism of E1 reaction. - a) Explain the mechanism of halogenation of benzene.
b) Halogens are deactivating group but ortho & Para director. Give reasons. - What happens when propene is treated with hydrogen bromide? Discuss the mechanism involved in the presence and absence of peroxide.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Define with example a) Angle strain b) Huckel’s rule c) Poly nuclear hydrocarbons d) Electrophiles e) Nucleophiles.
- What happens when isobutyl alcohol is treated with sulphuric acid? Discuss the mechanism.
- Discuss the Bayer’s strain theory with limitations.
- Discuss allyl cation as resonance hybrid with orbital picture.
- Outline the mechanism of Perkin’s condensation.
- Explain ionisation of carboxylic acid and write the structure of carboxylate anion.
- Explain Cannizzaro condensation with mechanism.
- Write the Haworth synthesis of naphthalene.
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SHORT ANSWERS 10 x 2 = 20 Marks
- What is Williamson’s synthesis? Give an example.
- Write diazotisation reaction with example.
- Define and classify nitrenes.
- Write the stability of carbanion.
- Write the difference between E1 and E2 reaction.
- What is free radical substitution reaction? Give an example
- Classify free radicals with examples.
- Define functional and positional isomerism with example.
- Write the structure and IUPAC name of a) Acetic acid b) Formamide
- Write the structure of a) Aniline b) o-cresol
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