Download RGUHS B.Pharm 1st Year 2021 March 2604 Pharmaceutical Organic Chemistry I Revised Scheme 3 Question Paper

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Rajiv Gandhi University of Health Sciences, Karnataka

I Year B.Pharm Degree Examination — 23-Mar-2021

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Time: Three Hours Max. Marks: 70 Marks

PHARMACEUTICAL ORGANIC CHEMISTRY -1

(Revised Scheme 3)

Q.P. CODE: 2604

Your answers should be specific to the questions asked

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Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. Discuss ‘E1 and E2' reaction with mechanism, kinetics and orientation
2. Explain the addition of HBr to 1,3 - butadiene with mechanism & orientation
3. Explain (a) Cannizaro reaction (b) Beckmann’s rearrangement

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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks

4. Explain the conversion of carboxylic acid into (a) Acid chloride, (b) Amide (c) Ester (d) Anhydride
5. Explain NO₂ group is deactivating & m-directing but NH₂ group is activating & o-directing in aromatic electrophilic substitution reaction.
6. Explain the nitration of Benzene
7. Write a note on chlorination of methane

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8. Write short note on reactivity of alkyl halides towards SN1 reaction
9. What are cycloalkanes? Write any three methods of preparation of cycloalkanes.
10. Write a note on Diel’s Alder reaction
11. Explain the basicity of various amines & effect of substituents on basicity

SHORT ANSWERS 10 x 2 = 20 Marks

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12. What are Carbenes? Give example
13. Why o -nitrophenol is steam volatile but p-nitrophenol is not?
14. Kharasch peroxide effect
15. Write the structures of (a) 2-butenoic acid (b) 2-chloro-2-pentene
16. Example of stereochemical inversion

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17. Dipole moment
18. Reimer Tiemann reaction
19. Isomerism
20. Name the electrophiles used in Friedel Craft alkylation and sulphonation of benzene
21. Diazotization

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