Rajiv Gandhi University of Health Sciences, Karnataka
I Year B.Pharm Degree Examination - 21-Jun-2022
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Time: Three Hours Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY - I (RS-3)
Q.P. CODE: 2604
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- Discuss Bayer’s strain theory along with molecular orbital structure. Give any two preparations of cycloalkanes.
- Discuss the mechanism of addition of hydrogen bromide to unsymmetrical alkenes in presence and absence of peroxides.
- What are activating and deactivating groups? Explain the mechanism of nitration and halogenation of benzene.
SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
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- Why amines are basic? Explain the effect of substituents on the basicity of amines.
- Give the mechanism of Knoevenagel’s and Reformatsky reactions.
- Discuss the stability of allyl radical with its orbital picture.
- Write the mechanism and stereochemistry of SN2 reaction.
- What is Saytzeff's rule? Give example with mechanism.
- Discuss diazotization and diazo coupling reactions.
- What is isomerism? Discuss different types of isomerism with examples.
- Explain the factors that affect SN1 reaction.
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SHORT ANSWERS 10 x 2 = 20 Marks
- What are aprotic solvents? Give examples.
- Define free radicals.
- Give the IUPAC names for acetone and chloroform.
- Define nucleophile. Give examples.
- Among acetic acid and chloroacetic acid, which is more acidic and why?
- Enlist ortho-para directing groups.
- How do you convert benzoic acid into ethyl benzoate?
- What is Smith Rearrangement? Give example.
- What are conjugated dienes? Give example.
- State Huckel’s rule with examples.
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