Download WBUHS 2nd Year 2022 May Pathology Paper I Question Paper

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The West Bengal University of Health Sciences

MBBS 2nd Professional Examination (New Regulation) May 2022

Subject: Pathology

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Paper: I

Full Marks: 100

Time: 3 hours

Attempt all questions. The figures in the margin indicate full marks.

1. a) A 42 year old male with H/O RTA presented with a lacerated injury of soft tissue of lower limbs without any fracture of bones. 2+5+3+5

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   1. What tissue will replace this devitalised injured tissue in the process of healing?
   2. What are different stages of healing here?
   3. What are the differences between healing by primary intention and by secondary intention?
   4. Enumerate important complications of healing.

   b) A 30 year old female presented with severe anaemia, weakness and dyspnoea. Blood examination showed: Hb as 6.0 g/dl and low MCV. 5+5+5

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   1. What is your provisional diagnosis ?
   2. What laboratory tests will you perform to confirm the diagnosis ?
   3. Discuss the causes and pathogenesis of this condition.

2. a) What is an infarct ? Classify infarct and describe the factors that influence the development of an infarct. 2+4+4

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   b) Define shock. Describe pathogenesis of hypovolemic shock. 2+8

   c) What are conventional laboratory tests for thalassemia ? 10

3. Write short notes on following: 2 x 5

   1. Idiopathic thrombocytopenic purpura.

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   2. Role of AETCOM in medical teaching.

4. Explain the following statements: 5 x 4

   1. Metaplasia is a double-edged sword.
   2. Sickle cell trait patient are resistant to falciparum malaria.

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   3. Pre transfusion screening of blood is mandatory.
   4. Causes of oedema are multifactorial.
   5. HPV is an oncogenic virus.

5. Choose the correct option for each of the following:

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   1. All are true about chemokines except
      1. Small protein(8-11kd)
      2. Acts as chemoattractant
      3. Attracts monocytes
      4. Interferons are also included in this group

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   2. Naked granulomas are seen in -
      1. Wegener's granulomatosis
      2. Tuberculosis
      3. Syphilis
      4. Sarcoidosis

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   3. All are the effects of free radicals except
      1. Lipid peroxidation
      2. Oxidative change in protein
      3. Breaks in DNA
      4. Synthesis of new protein

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   4. Karyorrhexis refers to
      1. Cell membrane lysis
      2. Fading of cell nucleus
      3. Disintegration of cell nucleus
      4. Condensation of nucleus

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   5. The five stages of hemostasis are given below in random order. Put them in correct order
      a) clot dissolution b) blood coagulation c) vessel spasm d) clot retraction
      e) formation of platelet plug
      1. cabed
      2. acbde
      3. cebda

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      4. ecdba
   6. A malignant neoplasm is described as grade 1 on microscopic examination. What is the best interpretation with this
      1. Undifferentiated
      2. Moderately differentiated
      3. Well differentiated

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      4. Poorly differentiated
   7. Paraneoplastic syndrome is commonly seen with -
      1. Small cell carcinoma
      2. Colon adeno carcinoma
      3. Esophageal squamous cell carcinoma

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      4. Retinoblastoma
   8. Russel bodies are seen in
      1. Plasma cells
      2. Myeloblast
      3. Lymphoblast

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      4. Erythroblast
   9. Autoimmune hemolytic anaemia is seen in
      1. ALL
      2. AML
      3. CLL

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      4. CML
   10. All are features of Apoptosis except
       1. Cell size shrinkage
       2. Pyknosis of nucleus
       3. Cell membrane intact

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       4. Presence of inflammatory cells