Download WBUHS 2nd Year 2022 May Pharmacology Paper II Question Paper

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The West Bengal University of Health Sciences

MBBS 2nd Professional Examination (New Regulation) May 2022

Subject: Pharmacology

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Full Marks: 100

Paper: II

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Time: 3 hours

Attempt all questions. The figures in the margin indicate full marks.

1. 1. A 45 year old male visits to a physician with complaint of insomnia due to stress in the office. He was prescribed one Benzodiazepine as hypnotic.
   2. Enumerate two Benzodiazepines used as hypnotic.

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   3. Discuss mechanism of action and therapeutic uses of benzodiazepines as hypnotic.
   4. Compare and contrast: Benzodiazepines and Barbiturates. 2+4+4+5
2. 1. A 23 year old male arrives at emergency, with difficulty breathing, with history of recurrent episodes of seasonal breathlessness, relieved on inhalational medication. Now the patient is diagnosed as a case of bronchial asthma
   2. Classify the drug used in bronchial asthma.

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   3. How will you manage a case of acute bronchial asthma ?
   4. How do inhalational drugs act better in bronchial asthma ? 5+5+5
3. 1. Write a note on prophylactic treatment of malaria. Outline mechanism of action and four adverse effect of chloroquine. 5+3+2
   2. Classify oral contraceptives. Describe the clinical uses of contraceptives. 5+5

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   3. Enumerate the drugs used in peptic ulcer. How will you manage a case Helicobacter pylori infection? 5+5
4. Write short notes on following: 2 x 5
   1. Pharmacotherapy of diabetic ketoacidosis.
   2. Rifampicin (mechanism of action therapeutic uses, ADR).

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5. Explain the following statements: 5 x 4
   1. Corticosteroid use over long term can be harmful.
   2. Tricyclic antidepressants are not preferred in elderly male subjects.
   3. Injection thiopentone sodium is not used as a maintenance agent in general anesthesia.
   4. Ergometrine should not be used for induction of labour.
   5. Leucovorin rescue is mandatory in methotrexate therapy.

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6. Choose the correct option for each of the following: 10 x 1
   1. One of these is not an anabolic steroid.
      1. Stanozolol
      2. Delta tetrahydrocannabinol
      3. Oxandrolone
      4. Nandrolone

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   2. Actions of growth hormone include the following except:
      1. Increased protein synthesis
      2. Increased fat utilization
      3. Increased carbohydrate utilization
      4. Glucose intolerance

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   3. Which anti inflammatory agent is used in colon cancer.
      1. Prednisolon
      2. Celecoxib
      3. Indomethacin
      4. Colchicine

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   4. Which of these doesn't act on proton pump in stomach.
      1. Rabeprazole
      2. Esomeprazole
      3. Pirenzepine
      4. Pantoprazole

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   5. Drug of choice in Treponema pallidum infection
      1. Gentamicin
      2. Cefuroxim
      3. Azithromycin
      4. Penicillin

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   6. One of the opioids is so highly potent that it cannot be used in human.
      1. Buprenorphine
      2. Etorphine
      3. Codeine
      4. Morphine

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   7. The H1 Antihistaminic which is used topically in the nose for allergic rhinitis
      1. Loratadine
      2. Cetirizine
      3. Fexofenadine
      4. Azelastine

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   8. Local anaesthetic used in malignant hyperthermia is:
      1. Bupivacaine
      2. Procaine
      3. Cocaine
      4. Tetracaine

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   9. Which of the following is a 5HT receptor agonist ?
      1. Ondansetron
      2. Ketanserin
      3. Sumatriptan
      4. Risperidone

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   10. Carbimazole acts by inhibiting:
       1. Iodide trapping
       2. Oxidation of iodide
       3. Proteolysis of thyroglobulin
       4. Synthesis of thyroglobulin protein

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