CAUSES
CEREBRAL
SPINAL
PERIPHERAL
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CEREBRAL CAUSES
GRADUAL ONSET
SUDDEN ONSET
Parasagital meningioma
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Thrombosis of unpairedACA
Hydrocephalus
Cerebral diplegia
Superior sagital sinus
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SPINAL CAUSES
COMPRESSIVE
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NON -COMPRESSIVE
EXTRAMEDULLARY INTRAMEDULLARY
EXTRADURAL
INTRADURAL
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COMPRESIVE
EXTRAMEDULLARY
INTRAMEDULLARY
EXTRADURAL:
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Infection : abcess,Infection : TB spine, epidural
tuberculoma
abcess
Secondaries : breast, prostate,
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Syringomyelialungs, ovary
Primary tumors :
Trauma : disc prolapse
astrocytoma, glioma,
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INTRADURAL :ependymoma
Primary tumor :
neurofibroma, meningioma
AV malformations
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Infections : TB, syphillisFEATURES
EXTRAMEDULL INTRAMEDULLA
ARY
RY
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1. Root painEarly and common
Rare
2. Sensory deficit
No dissociation of pain Dissociation of sensation
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3. Sacral sensationLost ( early )
Sacral sparing
4. LMN involvement
Segmental
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Marked with widespreadatrophy
5. Reflexes
Brisk, early feature
Less brisk, late feature
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6. Autonomicinvolvement
Late
Early
(bowel and
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bladder)Usually not marked
Common
7. Trophic changes
May be sensitive to
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No bony tenderness8. Vertebral
local pressure
tenderness
Early and prominent
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Late and less pronounced9. UMN involvement Frequent
Rare
10. Changes in CSF
(protieins)
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NON COMPRESSIVE
Congenital
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TraumaVascular : Ant spinal artery occlusion, vasculitis,
SLE
Infection : syphillis, TB, varicella zooster, CMV
Demylination
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Primary : multiple sclerosisSecondary : post vaccination, para infectious
Nutrional : Vit B12 , lathyrism, Cu
Immunological : RA, sjogren's syndrome, Beheset's
disease
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Devlopmental : tethered cord syndrome, etcLMN TYPE OF LEISION
Lesion involving anterior horn cell
Acute anterior polymyelitis, Progressive
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muscular atrophy, TraumaLesion of peripheral nerve
GBS, cauda equina syndrome
Lesion of NMJ
Myasthenia gravis, drugs like aminoglycosides or
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organophosphorus insectisidesLesion in muscles
myopathy
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