Download PTU B-Tech Bio Technology 2020 Dec 6th Sem 71075 Computational Biology Question Paper

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Roll No. ‘ ‘ ‘ ‘ ‘ ‘ ‘ ‘ ‘ ‘ ‘ Total No. of Pages : 02

Total No. of Questions : 18

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B.Tech. (BT) (2012 to 2017) (Sem.-6)

COMPUTATIONAL BIOLOGY

Subject Code : BTBT-604

M.Code : 71075

Time : 3 Hrs. Max. Marks : 60

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INSTRUCTION TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of TEN questions carrying TWO marks each.
2. SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.
3. SECTION-C contains THREE questions carrying TEN marks each and students have to attempt any TWO questions.

SECTION-A

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Write briefly :

1. Radiation hybrid mapping
2. Eulerian cycle
3. AMBER
4. MMDB

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5. Gene Hunting
6. Optical maps
7. Restriction mapping tool
8. Application of Lander-waterman in bioinformatics
9. Fuzzy Logic

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10. ADME

SECTION-B

1. Write the different features of KEGG database.
2. Explain the hidden Markov Model.
3. Write the important of docking in drug design. Differentiate between rigid and flexible docking.

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4. Write the important steps required in finding target template to model the three dimensional structural of protein based on homology modeling approach.
5. Write a perl programme which can be used to convert any sequence format to GenBank sequence format.

SECTION-C

1. Explain the concepts of evolutionary computing. With example, write the application of evolutionary computing in bioinformatics.
2. Describe different bioinformatics methods of gene prediction? How prokaryotic gene prediction tool is different from eukaryotic gene prediction tool?

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3. Explain DNA double and partial digest. What are the problems encountered during these digestion of DNA? Write solutions to solve the double and partial digest problem.

NOTE : Disclosure of identity by writing mobile number or making passing request on any page of Answer sheet will lead to UMC case against the Student.