(b) Phenylketonuria and Alkaptonuria
(c) Role of liver in integration of metabolism
(d) Gout (4X5)
Q3. Ten multiple choice questions: (1 mark each)
- An enzyme required for the synthesis of ketone bodies as well as cholesterol is:
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A) Acetyl CoA carboxylase
B) HMG CoA synthetase
C) HMG CoA reductase
D) HMG CoA lyase - The physiological uncoupler of oxidative phosphorylation is:
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A) 2,4-dinitrophenpl
B) Dinitrocresol
C) Thermogenin
D) Valinomycin - NH3 is removed from brain mainly by:
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A) Urea formation
B) Uric acid production
C) Glutathion
D) Glutamine formation - Which urine test will be positive for patient with maple syrup urine disease?
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A) Dinitophenyl hydrazine test
B) Benedict's test
C) Ferric chloride test
D) Cyanide nitroprusside test - Homogentisic acid is excreted in urine in:
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A) Phenylketonuria
B) Maple syrup urine disease
C) Tyrosinosis
D) Alkaptonuria - Niacin deficiency can occur in:
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A) Hartnup's disease
B) Phenylketonuria
C) Alkaptonuria
D) None of these - Refsum's disease results from a defect in the following pathway:
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A) Alpha-oxidation of fatty acids
B) Beta-oxidation of fatty acids
C) Gamma-oxidation of fatty acids
D) Omega-oxidation of fatty acids - Gold standard marker for GFR (glomerular filtration rate) estimation is:
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A) Urea clearance
B) Cystatin clearance
C) Creatinine clearance
D) Inulin clearance - The active transport system for hepatic uptake of bilirubin is congenitally defective in
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A) Gilbert's disease
B) Crigler-Najjar syndrome
C) Rotor's syndrome
D) Dubin-Johnson syndrome - Activated lecithin cholesterol acyl transferase is essential for the conversion of:
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A) Nascent LDL into LDL
B) Nascent HDL into HDL
C) HDL2 into HDL3
D) HDL3 into HDL2
Max marks 50
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MBBS Biochemistry Paper
Q1. Discuss the mechanism of action of enzymes and the types of enzyme inhibition. Explain how enzymes have been used for therapeutics and diagnostics. (20)
Q2. Write briefly on:
(a) Glycosaminoglycans
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(b) Lysosomal storage diseases
(c) Wilson's disease
(d) Secondary structure of protein (4X5)
Q3. Ten multiple choice questions: (1 mark each)
- In case of competitive enzyme inhibition
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A) Vmax increases while Km remains the same
B) Vmax decreases while Km remains the same
C) Vmax remains the same while Km increases
D) Vmax remains the same while Km decreases - Monosaccharides other than Glucose and Galactose are absorbed by:
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A) Carrier-mediated diffusion
B) Passive diffusion
C) Active transport
D) Secondary active transport - Which one of the following is a phospholipid?
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A) Prostaglandins
B) Cerebroside
C) Cholesterol
D) Lecithin - The pentose sugar mainly present in the heart tissue is:
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A) Lyxose
B) Ribose
C) Arabinose
D) Xylose - The most effective blood buffer is:
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A) Citric acid buffer
B) Carbonic acid buffer
C) Phosphate buffer
D) Glutamate buffer - Acrodermatitis enteropathica is due to defective absorption of:
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A) Manganese
B) Molybdenum
C) Iodine
D) Zinc - Which one of the following contains copper?
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A) Ceruloplasmin
B) Albumin
C) Glutathione peroxidase
D) Calcitonin - Fluoride ions in grey capped vacutainer inhibits
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A) Enolase
B) Hexokinase
C) Lactate dehydrogenase
D) Pyruvate dehydrogenase - Which of the following has the lowest concentration of cholesterol?
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A) Liver
B) Milk.
C) Chicken meat
D) Eggs - Mark the correct statement regarding Chylomicrons:
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A) Principally carry cholesterol
B) Are synthesized in small intestine
C) Are apolipoproteins
D) Are the smallest of lipoproteins
Max marks 50
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