TIME: 3 Hrs SUBJECT: MICROBIOLOGY PAPER- I Max. Marks: 100
Note: Attempt all questions. Answer PART- A and PART – B in separate answer books. All part of a question should be answered together.
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PART-A PAPER CODE: 2211130006
Q.1 Long Answer Question (2 + 3 + 5 + 5 = 15)
A 65 year old male was admitted to a hospital with complaints of severe pain in the lateral aspect of his right thigh and small amount of pus discharge from the ingrown hair.On physical examination, the local area was found to be red, warm and tender.Aspirated pus was subjected to Gram stain and showed Gram positive cocci in clusters.Culture on blood agar showed golden yellow pigmented beta-hemolytic colonies.
a) What is clinical diagnosis and its causative organism? (c) Describe the virulence factors of this organism
b) List the infections caused by this organism (d) Briefly discuss the laboratory diagnosis
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Q.2 Short Notes Questions (within 500 words) (5 x 3 = 15)
a) Difference between bacterial endotoxins and exotoxin
b) Gram Positive cocci infections
c) Importance of confidentiality pertaining to patient identity on lab results.
Q.3 Short Answer Questions (within 100 words) (2 x 5 = 10)
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a) Superantigens d) Graft versus host reaction
b) Immune complex mediated hypersensitivity reactions e) Differences between Disinfection and Sterilisation
c) Chronic granulomatous disease
Q.4 Multiple Choice Questions (1 x 10 = 10)
- 1 A patient who recently returned from camping in forest 2 The most effective way of preventing tetanus is: presents with malabsorption diarrhea. How does the most likely agent cause the diarrhea? (a) Hyperbaric oxygen (a) Co-infection with bacteria (b) Tissue debridement (b) Enterotoxin production (c) Tetanus toxoid (c) Suction disk attachment (d) Antibiotics (d) Tissue invasion leading to an inflammatory response and prostaglandin production
- 3 Aerosol Transmission occurs in all except: 4 "Malignant pustule" is a term used for (a) Mycobacterium tuberculosis (a) An infected melanoma (b) Pneumococcus (b) A carbuncle (c) Measles virus (c) A rapidly spreading rodent ulcer (d) Varicella (chickenpox and zoster) (d) Anthrax of the skin
- 5 If bacteriological examination of CSF is expected to be 6 Which antigen persist in Salmonella carrier state? delayed then it is stored as: (a) It is frozen (a) H antigen (b) It is kept at 37°C (b) M antigen (c)It is kept at room temperature (c) O antigen (d) Sample is discarded (d) Vi antigen
- 7 Which of the following waste should be pre-treated on-site 8 Number of Moments in Hand Hygiene as per World as per Bio Medical Waste Management guidelines 2016 Health Organization is (a) Expired/discarded medicines (a) 4 (b) Chemical solid waste (b) 5 (c) Microbiology, other clinical (c) 6 (d) Sharp waste (d) 10
- 9 Dermatophyte that does not affect nail: 10 Which of the following site is most commonly affected by Corynebacterium diphtheriae : (a) Trichphyton (a) Skin (b) Epidermophyton (c) Microsporum (b) Conjunctiva Faucial (d) Candida albicans (d) Kidney
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PART PAPER CODE: 2211230006
Q.1 Long Answer Question (2 + 3 + 5 + 5 = 15)
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A 6 year old boy was admitted to the hospital with complaints of high grade fever, headache, vomiting, altered mental status, seizure and neck rigidity. CSF was collected by lumbar puncture in a sterile container and sent to Microbiology lab.
(a) What is the probable clinical diagnosis?
(b) Enlist the bacterial etiological agents of this disease
(c) What is the pathogenesis of this disease?
(d) Briefly discuss the laboratory diagnosis
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Q.2 Short Notes Questions (within 500 words) (5x 3 = 15)
a) Personal Protective Equipments
b) Standard tests for Syphillis.
c) Bacterial zoonotic infections
Q.3 Short Answer Questions (within 100 words) (2 x 5 = 10)
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a) Enlist types of Culture media d) Bacterial aetiological agents of Urinary tract Infections
b) Difference between active and passive immunity e) Adjuvants
c) Life cycle of Chlamydia
Q.4 Multiple Choice Questions (1 x 10 = 10 )
- 1 A 32 year old male has got clean wound without 2 Which of the following is not a cause of laceration. He had a booster dose of TT 6 years neonatal meningitis? ago. What is the next line of management? (a) Wound care with single dose of tetanus toxoid (a) Escherichia coli (b) Wound care with human tetanus Ig with tetanus (b) Streptococcus agalactia (c) Wound care with complete course of tétanus toxoid (c) Listeria monocytogenes (d) Wound care with no immunisation (a) Streptococcus pneumonia
- 3 Which culture medium is preferred for culture of urine 4 Causes of Non gonococcal urethritis are specimens? all, Except: (a) TCBS agar (a) Chlamydia trachomatis (b) CLED agar (b) Herpes simplex virus (c) Chocolate agar (c) Candida albicans (d) XLD agar (d) Treponemapallidum
- 5 Plague is transmitted by: 6 Hand rub should NOT be used in which condition (a) Rat flea (a) Before touching patient (b) Soft tick (b) After touching patient (c) Hard tick (c) After touching patient surroundings (d) Louse (d) Hands are visibly soiled
- 7 Which of the following disinfectants is NOT used 8 Solid waste items contaminated with blood and currently for disinfection of operation theatres? body fluids including cotton dressings belong to which category of biomedical waste? (a) Formaldehyde (a) Yellow (b) Glutaraldehyde based (b) Red (c) Hydrogen peroxide based (c) Blue (3) Quarternary ammonium compound (d) White
- 9 The decreasing order of risk of transmission following 10 Which of the following agent of meningitis can occupational exposure: grow on chocolate agar but not on blood agar? (a) HIV > HBV > HCV (a) Neisseria meningitides (b) HBV > HIV > HCV (b) Haemophilus influenza (e) HBV > HCV > HIV (c) Moraxella catarrhalis (d) HCV > HBV > HIV Escherichia coli
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