KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE ? 506 007
1st M.B.B.S. EXAMINATIONS (NEW REGULATION) ? NOVEMBER 2020
BIOCHEMISTRY PAPER ? I
Time: 3 Hours Max Marks: 100
necessary.
Long Answer Questions (2 X 15 = 30)
1. A 70-year-old woman was admitted with severe congestive cardiac
failure. She has been unwell for about a week and was not on any
distressed. She was on an oxygen mask. Admission biochemistry
investigations are listed below: pH-7.58, HCO-19mmol/L, pCO-21mm
Hg, pO-154 mm Hg
o i. What are the critical course of events that will alter her acid-
o ii. What acid-base abnormalities would you expect in her based on
the above information?
o iii. Discuss the compensatory mechanisms which will take place in
this patient.
o v. Which sample is sent for analysis of the blood gases? Name the
precautions which need to be taken during collection and
transport of the sample.
2. What are isoenzymes? What are the different ways in which isoenzymes
creatine kinase (CK) and lactate dehydrogenase (LDH).
Short Answer Questions (8x5=40)
3. Explain the electron transport chain. Mention the sites of ATP synthesis.
Add a note on inhibitors of oxidative phosphorylation.
gluconeogenesis.
5. Describe the formation and fate of ketone bodies. Add a note on ketosis.
6. Using a neat and labelled diagram explain the fluid mosaic model of the
cell membrane. Discuss the importance of membrane lipids.
fractions obtained on electrophoresis.
8. Classify hormones based on the chemical nature. Discuss in detail the
mechanism of action of steroid hormones.
9. What do you understand by phase-2 reactions of detoxification? Explain
10. What are mucopolysaccharides? Discuss the different types along with
their chemistry and function.
Very Short Answer Questions (10X3=30)
11. Importance of carnitine shuttle pathway.
13. Write in brief about the therapeutic utility of enzymes with examples.
14. What are normal levels of serum electrolytes? List out a few causes of
hyperkalemia.
15. Oxidative stress and its effects.
17. Chemistry and functions of Cholesterol.
18. Explain the triple helical structure of a collagen molecule.
19. What are the principles of photometry? Define them.
20. What is plasma osmolality? Mention its clinical importance.
WARANGAL, TELANGANA STATE ? 506 007
1st M.B.B.S. EXAMINATIONS (NEW REGULATION) ? NOVEMBER 2020
BIOCHEMISTRY PAPER ? I
Time: 3 Hours Max Marks: 100
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Note: Answer all questions. Give Diagrammatic representation wherevernecessary.
Long Answer Questions (2 X 15 = 30)
1. A 70-year-old woman was admitted with severe congestive cardiac
failure. She has been unwell for about a week and was not on any
--- Content provided by FirstRanker.com ---
medication. On examination, she was hyperventilating and was verydistressed. She was on an oxygen mask. Admission biochemistry
investigations are listed below: pH-7.58, HCO-19mmol/L, pCO-21mm
Hg, pO-154 mm Hg
o i. What are the critical course of events that will alter her acid-
--- Content provided by FirstRanker.com ---
base status?o ii. What acid-base abnormalities would you expect in her based on
the above information?
o iii. Discuss the compensatory mechanisms which will take place in
this patient.
--- Content provided by FirstRanker.com ---
o iv. Will electrolyte analysis help in this patient? If yes, how?o v. Which sample is sent for analysis of the blood gases? Name the
precautions which need to be taken during collection and
transport of the sample.
2. What are isoenzymes? What are the different ways in which isoenzymes
--- Content provided by FirstRanker.com ---
can be identified? Discuss the clinical importance of isoenzymes ofcreatine kinase (CK) and lactate dehydrogenase (LDH).
Short Answer Questions (8x5=40)
3. Explain the electron transport chain. Mention the sites of ATP synthesis.
Add a note on inhibitors of oxidative phosphorylation.
--- Content provided by FirstRanker.com ---
4. Enumerate the gluconeogenic substrates and describe the reactions ofgluconeogenesis.
5. Describe the formation and fate of ketone bodies. Add a note on ketosis.
6. Using a neat and labelled diagram explain the fluid mosaic model of the
cell membrane. Discuss the importance of membrane lipids.
--- Content provided by FirstRanker.com ---
7. What are lipoproteins? Discuss the functions of different lipoproteinfractions obtained on electrophoresis.
8. Classify hormones based on the chemical nature. Discuss in detail the
mechanism of action of steroid hormones.
9. What do you understand by phase-2 reactions of detoxification? Explain
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the concept using an example of bilirubin.10. What are mucopolysaccharides? Discuss the different types along with
their chemistry and function.
Very Short Answer Questions (10X3=30)
11. Importance of carnitine shuttle pathway.
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12. Hypersensitivity reactions.13. Write in brief about the therapeutic utility of enzymes with examples.
14. What are normal levels of serum electrolytes? List out a few causes of
hyperkalemia.
15. Oxidative stress and its effects.
--- Content provided by FirstRanker.com ---
16. Significance of uronic acid pathway.17. Chemistry and functions of Cholesterol.
18. Explain the triple helical structure of a collagen molecule.
19. What are the principles of photometry? Define them.
20. What is plasma osmolality? Mention its clinical importance.
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