PAPER CODE: MB2019103
KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES WARANGAL,
TELANGANA STATE ? 506 002
MBBS FIRST YEAR EXAMINATIONS: NOVEMBER, 2023
BIOCHEMISTRY (New Regulation) PAPER -II
Note: Answer all questions Draw diagrams wherever necessary with Black Ball
point pen /HB pencil /any dark Colour pencil
________________________________________________________________
Multiple Choice Questions: 10 X 1 = 10
a) Single bond in character
b) Double bond in character
c) Partial double bond in character
d) Triple bond in character
a) Ammonia and Arginine
b) Ammonia and Aspartic acid
c) Both from Ammonia
d) Ammonia and Ornithine
a) Ornithine and citrulline
b) Oxalosuccinate and formic acid
c) Oxaloacetate and aspartic acid
d) Ascorbic acid and Glycine
a) Bronchiectasis
b) Nephrotic syndrome
c) Coronary artery disease
d) Diabetes mellitus
a) Two strands are covalently bonded
b) Two strands are antiparallel
c) Strands have polarity
d) Strands are complementary to each other
a) Multiple myeloma
b) Xanthanuria
c) Psoriasis
d) Polycythemia vera
a) Silent mutation
b) Mis-sense mutation
c) Nonsense mutation
d) Frameshift mutation
8. Which of the following renal functional tests are used to measure the
Glomerular Filtration Rate (GFR)
a) Clearance tests
b) Urine concentration tests
d) Urine acidification tests
9. Which is an anticancer drug.
a) Zidovudine
b) 6-mercaptopurine
d) Acyclovir
10. Okazaki fragments occur on the
a) Leading strand
b) Lagging strand
d) All the above
Essay/ Long Answer Questions: 2 X 15 = 30
11. A 15-year-old boy complained of swelling and pain in the distal
phalangeal joints. Blood investigations showed the following results. On
allopurinol. a. What is your probable diagnosis in the above patient. b.
Write the synthesis of Uric Acid. serum - 12 mg/dL c. What is the normal
uric acid level? d. What are other blood investigations would you
suggest. e. Comment on the serum uric acid level and explain the cause
of pain in joints. f. Write the ways for lowering serum uric acid level. g.
What is the biochemical explanation for the treatment given in the
above patient. (1+3+2+3+3+3)
12. Describe the steps of catabolism of Phenylalanine and Tyrosine. Indicate
the inborn errors of metabolism. What are the Biomedically important
Short Answer Questions: 7 X 6 = 42
13. Name the enzymes measured to assess liver functions. Discuss the
clinical significance of Alanine transaminase and Alkaline phosphatase in
assessing liver function.
forms of DNA.
15. Write on the classification of Acid-base disorders in the body and also
mention the compensatory mechanisms for each type.
16. Justify the statement "Physician is a lifelong learner".
18. What are tumour markers. Discuss the clinical utility of any three tumour
markers.
19. Write about structure, classification and functions of immunoglobulins.
Very Short Answer Questions: 6 X 3 = 18
21. List the thyroid function tests. Mention the laboratory findings in a case
of hypothyroidism.
22. What is Polymerase Chain Reaction (PCR). Mention two clinical
applications of PCR technique.
24. What is foetal haemoglobin. How does its structure differ from adult
haemoglobin and explain how it is useful to the foetus.
25. ACTH.
*****
KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES WARANGAL,
TELANGANA STATE ? 506 002
MBBS FIRST YEAR EXAMINATIONS: NOVEMBER, 2023
BIOCHEMISTRY (New Regulation) PAPER -II
--- Content provided by FirstRanker.com ---
Time: 3 Hours Max Marks:100Note: Answer all questions Draw diagrams wherever necessary with Black Ball
point pen /HB pencil /any dark Colour pencil
________________________________________________________________
Multiple Choice Questions: 10 X 1 = 10
--- Content provided by FirstRanker.com ---
1. Peptide bond isa) Single bond in character
b) Double bond in character
c) Partial double bond in character
d) Triple bond in character
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2. During urea cycle, the two nitrogen atoms are derived froma) Ammonia and Arginine
b) Ammonia and Aspartic acid
c) Both from Ammonia
d) Ammonia and Ornithine
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3. The sources of oxalic acid in urine area) Ornithine and citrulline
b) Oxalosuccinate and formic acid
c) Oxaloacetate and aspartic acid
d) Ascorbic acid and Glycine
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4. Elevated homocysteine levels are associated with a risk ofa) Bronchiectasis
b) Nephrotic syndrome
c) Coronary artery disease
d) Diabetes mellitus
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5. Regarding DNA structure which is not correct.a) Two strands are covalently bonded
b) Two strands are antiparallel
c) Strands have polarity
d) Strands are complementary to each other
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6. Which of the following conditions is not associated with hyperuricemia.a) Multiple myeloma
b) Xanthanuria
c) Psoriasis
d) Polycythemia vera
--- Content provided by FirstRanker.com ---
7. Sickle cell anaemia occurs due toa) Silent mutation
b) Mis-sense mutation
c) Nonsense mutation
d) Frameshift mutation
--- Content provided by FirstRanker.com ---
8. Which of the following renal functional tests are used to measure the
Glomerular Filtration Rate (GFR)
a) Clearance tests
b) Urine concentration tests
--- Content provided by FirstRanker.com ---
c) Urine dilution testsd) Urine acidification tests
9. Which is an anticancer drug.
a) Zidovudine
b) 6-mercaptopurine
--- Content provided by FirstRanker.com ---
c) Allopurinold) Acyclovir
10. Okazaki fragments occur on the
a) Leading strand
b) Lagging strand
--- Content provided by FirstRanker.com ---
c) Double helical DNA strandd) All the above
Essay/ Long Answer Questions: 2 X 15 = 30
11. A 15-year-old boy complained of swelling and pain in the distal
phalangeal joints. Blood investigations showed the following results. On
--- Content provided by FirstRanker.com ---
diagnosing the pathology, the physician decided to treat patient withallopurinol. a. What is your probable diagnosis in the above patient. b.
Write the synthesis of Uric Acid. serum - 12 mg/dL c. What is the normal
uric acid level? d. What are other blood investigations would you
suggest. e. Comment on the serum uric acid level and explain the cause
--- Content provided by FirstRanker.com ---
of pain in joints. f. Write the ways for lowering serum uric acid level. g.
What is the biochemical explanation for the treatment given in the
above patient. (1+3+2+3+3+3)
12. Describe the steps of catabolism of Phenylalanine and Tyrosine. Indicate
the inborn errors of metabolism. What are the Biomedically important
--- Content provided by FirstRanker.com ---
compounds derived from tyrosine. (8+5+2)Short Answer Questions: 7 X 6 = 42
13. Name the enzymes measured to assess liver functions. Discuss the
clinical significance of Alanine transaminase and Alkaline phosphatase in
assessing liver function.
--- Content provided by FirstRanker.com ---
14. Discuss the Watson and Crick model of DNA. Add a note on differentforms of DNA.
15. Write on the classification of Acid-base disorders in the body and also
mention the compensatory mechanisms for each type.
16. Justify the statement "Physician is a lifelong learner".
--- Content provided by FirstRanker.com ---
17. Describe the formation of bilirubin. Name the different types of jaundice.18. What are tumour markers. Discuss the clinical utility of any three tumour
markers.
19. Write about structure, classification and functions of immunoglobulins.
Very Short Answer Questions: 6 X 3 = 18
--- Content provided by FirstRanker.com ---
20. Orotic aciduria.21. List the thyroid function tests. Mention the laboratory findings in a case
of hypothyroidism.
22. What is Polymerase Chain Reaction (PCR). Mention two clinical
applications of PCR technique.
--- Content provided by FirstRanker.com ---
23. Importance of cytochrome P450 in detoxification.24. What is foetal haemoglobin. How does its structure differ from adult
haemoglobin and explain how it is useful to the foetus.
25. ACTH.
*****
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