KAIJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE ? 506 002
MBBS SECOND YEAR DEGREE EXAMINATIONS: AUGUST 2025
PHARMACOLOGY PAPER-I
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Time: 3 Hours Max Marks: 100Note: Answer all questions Give Diagrammatic representation where ever
necessary
Multiple Choice Questions: 10 X 1 = 10
1. Drug administered through the following route is most likely to be
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subjected to first-pass metabolism:a) Oral
b) Sublingual
c) Subcutaneous
d) Rectal
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2. Orphan drugs area) drugs with high therapeutic failure
b) drugs for rare disease
c) drugs having low therapeutic margin
d) drugs with high toxicity
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3. Low doses of aspirin prolong bleeding time by selectively inhibitingsynthesis of the following mediator in the platelets:
a) Thromboxane A22
b) 5-Hydroxytryptamine3
c) Platelet activating factor4
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d) Prostacycl5in
4. The most effective drug in parkinsonism is:
a) Bromocriptine
b) Selegiline
c) Levodopa
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d) Biperiden5. The following analgesic lacks anti-inflammatory action:
a) Paracetamol
b) Ibuprofen
c) Diclofenac sodium
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d) Piroxicam6. The drug which undergoes 'Hofmann' elimination is:
a) Succinylcholine
b) Pancuronium
c) Vecuronium
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d) Atracurium7. Fomepizole is used in which poisoning
a) methyl alcohol poisoning
b) morphine poisoning
c) strychnine poisoning
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d) atropine poisoning8. Atropine poisoning causes all except
a) Dilated pupil
b) Excessive salivation
c) Excitement
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d) hot skin
9. Antidote for paracetamol poisoning is
a) Naloxone
b) Methylene blue
c) N-acetylcysteine
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d) Flumazenil10. The drug of choice for status epilepticus is
a) Lorazepam
b) Propofol
c) Thiopentone
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d) Sodium valproateEssay/ Long Answer Questions: 2 X 15 = 30
11. a) Enlist the different types of receptors with examples of drugs acting
through them. (6+2)
b) Describe the factors modifying drug action and their clinical significance.
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(5+2)12. Classify Antidepressants. Describe the mechanism of action, therapeutic
uses and adverse effects of Tricyclic Antidepressants. (6+3+3+3)
Short Answer Questions: 7 X 6 = 42
13. Describe the advantages and disadvantages of Intravenous route of Drug
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administration.14. Compare and contrast Succinylcholine and D-Tubocurarine.
15. Describe therapeutics uses and adverse effects of Alpha Blockers.
16. Classify Anticholinesterases and mention their therapeutic uses.
17. Explain the mechanisms of action, therapeutic uses and adverse effects
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of proton Pump Inhibitors.18. Describe disease modifying Anti Rheumatoid Drugs.
19. Describe how to counsel HIV/ AIDS patient to adhere to Anti-Retroviral
Therapy.
Very Short Answer Questions: 6 X 3 = 18
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20. Define Prodrug with two examples.21. Enlist any two uses of Adrenaline with its rationale.
22. Mention the drugs used in the management of Organo Phosphorous
Poisoning with its rationale.
23. Mention three different groups of drugs used in Bronchial Asthma with
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one example for each.24. What is Malignant Hyperthermia? Mention the drug used for its
treatment.
25. Define Tachyphylaxis. Give two examples of drugs causing Tachyphylaxis.
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