Total No. of Pages : 02
Roll No.
Total No. of Questions : 13
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B.Pharma (2017 Batch) (Sem.-4)
MEDICINAL CHEMISTRY-I
Subject Code : BP-402T M.Code: 75844
Time: 3 Hrs. Max. Marks : 75
INSTRUCTIONS TO CANDIDATES :
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- SECTION-A is COMPULSORY consisting of TEN questions carrying TWO marks each.
- SECTION-B contains THREE questions carrying TEN marks each and student has to attempt any TWO questions.
- SECTION-C contains NINE questions carrying FIVE marks each and student has to attempt any SEVEN questions.
SECTION-A
Q1. Answer briefly :
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- What is the mechanism of action and uses of ephedrine?
- Define Bioisosteres.
- Give the structure of any one urea derivative acting as anticonvulsant agent.
- Write a note on catabolism of acetylcholine.
- Give the structure and name of alpha blocker having quinazoline moiety.
- Name any two NSAIDs. Give their moa.
- Outline the synthesis of barbital.
- Give the structure of any one reactivator of organophosphate poisoning.
- What are dissociative anesthetics?
- Give the structure of benzodiazepine derivative acting as anticonvulsant agent.
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SECTION-B
Q2. Classify Antipsychotic agents giving the structure of atleast one drug belonging to each category. Comment upon the SAR, moa and uses of phenothiazine class of drugs.
Q3. Give the chemical name, moa, the synthetic procedure and uses of the following drugs :
- Carbamezepine
- Diazepam
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Q4. Discuss in detail the chemistry of :
- Morphine analogs
- Ultra short acting barbiturates
SECTION-C
Q5. Comment upon various factors affecting drug metabolism.
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Q6. Outline various steps involved in the synthesis of ibuprofen. Discuss its role as anti- inflammatory agent.
Q7. Discuss the SAR of benzodiazepines.
Q8. Classify anticholinergic agents. Give atleast two examples of each class.
Q9. Write a short note on history and development of medicinal chemistry.
Q10. Discuss the biological importance and chemistry of hydantoin derivatives.
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Q11. Write a short note on narcotic antagonists.
Q12. Explain the chemistry of AchE inhibitors.
Q13. Classify Anticonvulsants. Suggest their mechanism of action.
NOTE: Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.
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This download link is referred from the post: PTU B.Pharma 4th Semester Last 10 Years 2011-2021 Previous Question Papers|| Punjab Technical University
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