D
r. . MEDICAL
[MBBS 0825] AUGUST 2025 Sub. Code: 7056
(For the candidates admitted from the Academic Year 2024-2025)
FIRST PROFESSIONAL ? (CBME)
PAPER II ? BIOCHEMISTRY
Time: Three hours
Maximum: 100 Marks (80 Theory + 20MCQs)
Answer All Questions
(1 x 10 = 10)
1. Explain the different levels of structural organization of protein with
hemoglobin as an example.
II. Reasoning out short notes:
(2 x 5 = 10)
1. Orotic aciduria can occur in Ornithine Transcarbomylase deficiency. Explain.
b) Explain the reason for mousy body odour in phenylketonuria.
III. Write Short notes on:
(10 x 6 = 60)
Investigation revealed hyperammonemia and respiratory alkalosis. The treating
physician managed the acute episode well and advised low protein supplements.
a) What is the reference range for Urea and BUN in serum? (1)
b) Tabulate the disorders of urea cycle with the enzyme defect. (5)
3. a) Discuss any two biomarkers of sepsis. (3)
b) Explain the mode of inheritance of Hemophilia? (3)
4. Describe the metabolic reactions that need tetrahydrobiopterin as a cofactor.
5. a) A 39 year old antenatal mother on 12th week of gestation goes for check-up.
Quadruple screening test in antenatal mothers. (2)
b) Role of tumour markers in diagnosis of diseases. (4)
6. Enumerate the liver function tests. Discuss the markers of liver injury (2+4)
7. A 75 year old male came to OPD with complaints of low back ache, anaemia,
a peculiar protein and serum protein electrophoresis had a charateristic band in
the gamma region.
a) What is the probable diagnosis? Name the protein excreted in urine of the
patient. (2)
... 2 ...
... 2 ....
8. Explain the Renal regulation of acid base balance.
9. A 50 year old male patient attended nephrology clinic for decreased urine
addition to other tests. (2 +2+2)
a) Significance of Estimated GFR (eGFR).
b) Comment on Plasma Osmolality.
C) Indication of urine microalbumin test.
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[MBBS 0825]
r. . MEDICAL
[MBBS 0825] AUGUST 2025 Sub. Code: 7056
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M.B.B.S. DEGREE EXAMINATION(For the candidates admitted from the Academic Year 2024-2025)
FIRST PROFESSIONAL ? (CBME)
PAPER II ? BIOCHEMISTRY
--- Content provided by FirstRanker.com ---
Q.P. Code: 527056Time: Three hours
Maximum: 100 Marks (80 Theory + 20MCQs)
Answer All Questions
--- Content provided by FirstRanker.com ---
I. Essay:(1 x 10 = 10)
--- Content provided by FirstRanker.com ---
1. Explain the different levels of structural organization of protein with
hemoglobin as an example.
II. Reasoning out short notes:
--- Content provided by FirstRanker.com ---
(2 x 5 = 10)
1. Orotic aciduria can occur in Ornithine Transcarbomylase deficiency. Explain.
--- Content provided by FirstRanker.com ---
2. a) Phenylalanine has sparing action on Tyrosine. Discuss the statement.b) Explain the reason for mousy body odour in phenylketonuria.
III. Write Short notes on:
--- Content provided by FirstRanker.com ---
(10 x 6 = 60)
--- Content provided by FirstRanker.com ---
1. A 4 day old newborn presented with vomiting, lethargy and irritability.Investigation revealed hyperammonemia and respiratory alkalosis. The treating
physician managed the acute episode well and advised low protein supplements.
a) What is the reference range for Urea and BUN in serum? (1)
b) Tabulate the disorders of urea cycle with the enzyme defect. (5)
--- Content provided by FirstRanker.com ---
2. Brief the synthesis a Physiological actions of Nitric Oxide.3. a) Discuss any two biomarkers of sepsis. (3)
b) Explain the mode of inheritance of Hemophilia? (3)
4. Describe the metabolic reactions that need tetrahydrobiopterin as a cofactor.
5. a) A 39 year old antenatal mother on 12th week of gestation goes for check-up.
--- Content provided by FirstRanker.com ---
Her doctor advises Quadruple Screening test. Discuss the significance ofQuadruple screening test in antenatal mothers. (2)
b) Role of tumour markers in diagnosis of diseases. (4)
6. Enumerate the liver function tests. Discuss the markers of liver injury (2+4)
7. A 75 year old male came to OPD with complaints of low back ache, anaemia,
--- Content provided by FirstRanker.com ---
hyperproteinemia with increase of Globulin fraction, Urine positive fora peculiar protein and serum protein electrophoresis had a charateristic band in
the gamma region.
a) What is the probable diagnosis? Name the protein excreted in urine of the
patient. (2)
--- Content provided by FirstRanker.com ---
b) Discuss the electrophoretic patterns in any two diseases. (4)... 2 ...
... 2 ....
8. Explain the Renal regulation of acid base balance.
9. A 50 year old male patient attended nephrology clinic for decreased urine
--- Content provided by FirstRanker.com ---
output. The clinician suspected a chronic kidney disease and ordered eGFR inaddition to other tests. (2 +2+2)
a) Significance of Estimated GFR (eGFR).
b) Comment on Plasma Osmolality.
C) Indication of urine microalbumin test.
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10. Role of physician in health care system.*********
[MBBS 0825]
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