MEDICAL
[MBBS 0325] MARCH 2025 Sub. Code :6062
M.B.B.S. DEGREE EXAMINATIONS
(For the candidates admitted from the Academic Year 2019-2020)
PAPER II ? PHARMACOLOGY
Q.P. Code: 526062
Time: 20 Minutes
Answer All Questions
Shade the correct answer with Black of Blue ink ball point pen
SET - A
(20 x 1 = 20)
1. Somatostatin inhibits the release of:
2. Overtreatment with the following thyroid inhibitor results in enlargement of the thyroid:
A) Lugol's iodine B) Radioactive iodine C) Carbimazole D) All of the above
3. The second-generation sulfonylurea hypoglycaemics differ from the first-generation ones in
that they:
B) Are longer acting
C) Do not lower blood sugar in nondiabetic subjects
D) Are less prone to cause hypoglycaemic reaction
4. Select the compound that is preferred for high dose intravenous corticosteroid pulse therapy:
5. Finasteride acts by:
A) Blocking testosterone receptors in the prostate gland
B) Reducing testosterone secretion from testes
C) Reducing LH secretion from pituitary
6. Select the tissue that is most sensitive to oxytocin:
A) Myometrium B) Myoepithelium of mammary alveoli
C) Vascular smooth muscle D) Renal collecting ducts
7. Bisphosphonates are beneficial in the following conditions except:
8. The following antiulcer drug does not act by reducing the secretion or neutralizing gastric acid:
A) Magaldrate B) Sucralfate C) Misoprostol D) Omeprazole
9. Metoclopramide has the following actions except:
A) Increases lower esophageal sphincter tone B) Increases tone of pyloric sphincter
... 2 ...
... 2 ...
10. Choose the correct statement about lactulose:
A) It stimulates myenteric neurons to enhance gut peristalsis
C) It is an osmotic laxative that produces soft but formed stools
D) All of the above
11. A 3-year-old child was given one tablet three times a day to control loose motions. The
diarrhoea stopped but next day the child was brought in a toxic condition with abdominal
sluggish reflexes. Which antidiarrhoeal drug could have caused this condition:
A) Iodochlorhydroxyquinline B) Furazolidone C) Loperamide D) Metronidazole
12. Trimethoprim is combined with sulfamethoxazole in a ratio of 1:5 to yield a steady state
plasma concentration ratio of:
C) Trimethoprim 1: Sulfamethoxazole 20 D) Trimethoprim 20: Sulfamethoxazole 1
13. If a patient gives history of urticaria, itching and swelling of lips following injection of
penicillin G, then:
A) He will develop similar reaction whenever penicillin is injected
C) He can be given oral phenoxymethyl penicillin safely
D) All natural and semisynthetic penicillins are contraindicated for him
14. Combination therapy with two (or more) antimicrobials is superior to monotherapy with any
single effective drug in case of the following diseases except:
15. Which of the following antitubercular drugs is not hepatotoxic:
A) Isoniazid B) Rifampicin C) Pyrazinamide D) Ethambutol
16. The polyene antibiotics act by:
A) Inhibiting fungal cytochrome P450 enzyme
C) Inhibiting fungal DNA synthesis
D) Disorienting microtubules in fungal cells
17. Select the drug which directly inhibits HIV-reverse transcriptase without the need for
intracellular activation by phosphorylation:
18. Patients treated with the following anticancer drug are likely to develop a disulfiram like
reaction on taking alcohol:
A) Dacarbazine B) Procarbazine C) Melphalan D) Hydroxyurea
19. Drugs used for Pediculosis are all except
20. BAL is used as a Chelating agent for the following heavy metals except
A) Arsenic Poisoning B) Mercury Poisoning
C) Cadmium Poisoning D) Nickel Poisoning
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[MBBS 0325] MARCH 2025 Sub. Code :6062
M.B.B.S. DEGREE EXAMINATIONS
(For the candidates admitted from the Academic Year 2019-2020)
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SECOND PROFESSIONAL ? SUPPLEMENTARY - (CBME)PAPER II ? PHARMACOLOGY
Q.P. Code: 526062
Time: 20 Minutes
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Maximum : 20 MarksAnswer All Questions
Shade the correct answer with Black of Blue ink ball point pen
SET - A
--- Content provided by FirstRanker.com ---
III. Multiple Choice Questions:(20 x 1 = 20)
1. Somatostatin inhibits the release of:
--- Content provided by FirstRanker.com ---
A) Growth hormone B) Insulin C) Thyrotropin D) All of the above2. Overtreatment with the following thyroid inhibitor results in enlargement of the thyroid:
A) Lugol's iodine B) Radioactive iodine C) Carbimazole D) All of the above
3. The second-generation sulfonylurea hypoglycaemics differ from the first-generation ones in
that they:
--- Content provided by FirstRanker.com ---
A) Are more potentB) Are longer acting
C) Do not lower blood sugar in nondiabetic subjects
D) Are less prone to cause hypoglycaemic reaction
4. Select the compound that is preferred for high dose intravenous corticosteroid pulse therapy:
--- Content provided by FirstRanker.com ---
A) Cortisone B) Hydrocortisone C) Triamcinolone D) Methyl prednisolone5. Finasteride acts by:
A) Blocking testosterone receptors in the prostate gland
B) Reducing testosterone secretion from testes
C) Reducing LH secretion from pituitary
--- Content provided by FirstRanker.com ---
D) Lowering circulating as well as prostatic dihydrotestosterone concentration6. Select the tissue that is most sensitive to oxytocin:
A) Myometrium B) Myoepithelium of mammary alveoli
C) Vascular smooth muscle D) Renal collecting ducts
7. Bisphosphonates are beneficial in the following conditions except:
--- Content provided by FirstRanker.com ---
A) Paget's disease B) Senile osteoporosis C) Rickets D) Osteolytic bony metastasis8. The following antiulcer drug does not act by reducing the secretion or neutralizing gastric acid:
A) Magaldrate B) Sucralfate C) Misoprostol D) Omeprazole
9. Metoclopramide has the following actions except:
A) Increases lower esophageal sphincter tone B) Increases tone of pyloric sphincter
--- Content provided by FirstRanker.com ---
C) Increases gastric peristalsis D) Increases intestinal peristalsis... 2 ...
... 2 ...
10. Choose the correct statement about lactulose:
A) It stimulates myenteric neurons to enhance gut peristalsis
--- Content provided by FirstRanker.com ---
B) Administered orally it acts as a purgative within 2-4 hoursC) It is an osmotic laxative that produces soft but formed stools
D) All of the above
11. A 3-year-old child was given one tablet three times a day to control loose motions. The
diarrhoea stopped but next day the child was brought in a toxic condition with abdominal
--- Content provided by FirstRanker.com ---
distention and vomiting. He had paralytic ileus, mild dehydration, low blood pressure andsluggish reflexes. Which antidiarrhoeal drug could have caused this condition:
A) Iodochlorhydroxyquinline B) Furazolidone C) Loperamide D) Metronidazole
12. Trimethoprim is combined with sulfamethoxazole in a ratio of 1:5 to yield a steady state
plasma concentration ratio of:
--- Content provided by FirstRanker.com ---
A) Trimethoprim 1: Sulfamethoxazole 5 B) Trimethoprim 5: Sulfamethoxazole 1C) Trimethoprim 1: Sulfamethoxazole 20 D) Trimethoprim 20: Sulfamethoxazole 1
13. If a patient gives history of urticaria, itching and swelling of lips following injection of
penicillin G, then:
A) He will develop similar reaction whenever penicillin is injected
--- Content provided by FirstRanker.com ---
B) He can be given ampicillin safelyC) He can be given oral phenoxymethyl penicillin safely
D) All natural and semisynthetic penicillins are contraindicated for him
14. Combination therapy with two (or more) antimicrobials is superior to monotherapy with any
single effective drug in case of the following diseases except:
--- Content provided by FirstRanker.com ---
A) Typhoid fever B) Leprosy C) HIV D) Tuberculosis15. Which of the following antitubercular drugs is not hepatotoxic:
A) Isoniazid B) Rifampicin C) Pyrazinamide D) Ethambutol
16. The polyene antibiotics act by:
A) Inhibiting fungal cytochrome P450 enzyme
--- Content provided by FirstRanker.com ---
B) Binding to ergosterol and creating microporesC) Inhibiting fungal DNA synthesis
D) Disorienting microtubules in fungal cells
17. Select the drug which directly inhibits HIV-reverse transcriptase without the need for
intracellular activation by phosphorylation:
--- Content provided by FirstRanker.com ---
A) Nelfinavir B) Nevirapine C) Stavudine D) Didanosine18. Patients treated with the following anticancer drug are likely to develop a disulfiram like
reaction on taking alcohol:
A) Dacarbazine B) Procarbazine C) Melphalan D) Hydroxyurea
19. Drugs used for Pediculosis are all except
--- Content provided by FirstRanker.com ---
A) Permethrin B) Sulfur C) Crotamiton D) Gentian Violet20. BAL is used as a Chelating agent for the following heavy metals except
A) Arsenic Poisoning B) Mercury Poisoning
C) Cadmium Poisoning D) Nickel Poisoning
********
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[MBBS 0325]