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Download MBBS 1st Year 527053 Physiology Paper I Aug 2025 mcq Question Paper

Download MBBS (Bachelor of Medicine and Bachelor of Surgery) 1st Year 527053 Physiology Paper I Aug 2025 mcq Previous Question Paper

This post was last modified on 14 September 2025

D
r. . MEDICAL


[MBBS 0825] AUGUST 2025 Sub. Code: 7053

--- Content provided by‌ FirstRanker.com ---


M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2024-2025)

FIRST PROFESSIONAL ? (CBME)

--- Content provided by FirstRanker.com ---

PAPER I ? PHYSIOLOGY
Q.P. Code: 527053
Time: 20 Minutes

Maximum : 20 Marks

--- Content provided by⁠ FirstRanker.com ---

Answer All Questions
Shade the correct answer with Black or Blue ink ball point pen
SET - A
IV. Multiple Choice Questions:

--- Content provided by‌ FirstRanker.com ---



(20 x 1 = 20)
1. The release of hormones and neurotransmitters is an example of
A) Active Transport B) Vesicular Transport

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C) Facilitated Diffusion D) Pinocytocsis
2. The indicator used for the measurement of Plasma volume is
A) Inulin B) Deuterium C) Evans Blue D) Radio-labelled Chromium

3. Resting Membrane Potential of thick Spinal motor neurons

--- Content provided by‌ FirstRanker.com ---

A) -30 mV B) -45 mV C) -90 mV D) Fluctuating
4. Microcytic Hypochromic Anaemia is a features of
A) Thalassemia B) Acute Blood loss
C) Pernicious anaemia D) Sickle Cell anaemia
5. 18 years old Anjali, complaints of recurrent painful joint swelling, associated with profuse

--- Content provided by‍ FirstRanker.com ---

menstrual bleeding during her cycles. A diagnosis of Haemophilia was made. Coagulation
abnormality seen in a patient with Haemophilia B disease is
A) Prolonged PT B) Normal PT C) Normal APTT D) Prolonged APTT
6. Which protein blocks the myosin-binding site on actin in resting skeletal muscle?
A) Myosin B) Actin C) Troponin D) Tropomyosin

--- Content provided by FirstRanker.com ---

7. Fast-twitch muscle fibers (Type II) are characterized by:
A) High myoglobin content B) Slow contraction velocity
C) High resistance to fatigue D) Anaerobic metabolism
8. Which is true about smooth muscle contraction?
A) Relies exclusively on troponin for calcium binding B) Uses calmodulin instead of troponin

--- Content provided by⁠ FirstRanker.com ---

C) Requires somatic motor nerve stimulation D) Is faster than skeletal muscle contraction
9. Sarcomere length is decided by the length of
A) A band B) I band C) H band D) M line
10. Which of the following is the correct sequence of layers in the wall of the gastrointestinal
tract from inner to outer?

--- Content provided by‌ FirstRanker.com ---

A) Submucosa Mucosa Muscularis externa Serosa
B) Mucosa Submucosa Muscularis externa Serosa
C) Serosa Muscularis externa Submucosa Mucosa
D) Muscularis externa Mucosa Serosa Submucosa
... 2 ...

--- Content provided by‍ FirstRanker.com ---


... 2 ...

11. 18 years old Mr. Praveen, A II MBBS students while preparing for his exams complaints
of recurrent epigastric pain. Recurrent he is skipping his regular meals and taking pain
killers for his headache. Which cell is responsible for secreting hydrochloric acid in the

--- Content provided by⁠ FirstRanker.com ---

stomach
A) Chief cells B) G cells C) Parietal cells D) Mucous neck cells
12. 40 years old Kumaran, a known alcoholic experienced sudden onset of intractable
abdominal pain. His serum amylase and lipase levels are elevated. A diagnosis of acute
pancreatitis was made out which enzyme is secreted in its active form by the pancreas?

--- Content provided by‌ FirstRanker.com ---

A) Trypsin B) Chymotrypsin C) Amylase D) Carboxy peptidase
13. The defecation reflex is initiated primarily by:
A) Entry of food into the stomach B) Distention of the rectum
C) Secretion of bile into the duodenum D) Inhibition of sympathetic tone
14. Urea recycling is crucial for:

--- Content provided by FirstRanker.com ---

A) Maintaining acid-base balance B) Driving the countercurrent exchanger
C) Facilitating obligatory water loss D) Enhancing medullary osmolarity for urine concentration
15. The kidneys regulate extracellular fluid H+ concentration through all the three
fundamental mechanisms except
A) Direct H secretion B) Bicarbonate excretion

--- Content provided by‍ FirstRanker.com ---

C) Bicarbonate reabsorption D) Production of new bicarbonates
16. 65 years old male met with road traffic accident and sustained head injuries. Following
recovery he developed a Syndrome of Inappropriate Secretion of Anti diuretic Hormone
(SIADH). Which of the following is true regarding vasopressin (ADH)?
A) It is synthesized in the posterior pituitary

--- Content provided by⁠ FirstRanker.com ---

B) It increases water reabsorption via aquaporin-1 channels
C) It increases blood volume by acting on the collecting ducts
D) It increases potassium reabsorption
17. The majority of circulating thyroid hormones in blood are:
A) In the free form B) Bound to thyroxine-binding globulin (TBG)

--- Content provided by‍ FirstRanker.com ---

C) Bound to Transthyretin D) Bound to thyroxine-binding prealbumin (TBPA)
18. In a case of severe osteoporosis, Calcium supplements with Vitamin-D are prescribed.
Which organ is responsible for the final activation of vitamin D to calcitriol
(1,25-dihydroxycholecalciferol)?
A) Liver B) Kidney C) Intestine D) Skin

--- Content provided by‌ FirstRanker.com ---

19. Capacitation of sperm occurs:
A) In the epididymis B) In the seminal vesicle
C) In the female genital tract D) Inside the seminiferous tubules
20. 28 years old female, a case of recurrent abortions was evaluated and a diagnosis of luteal
phase defect was made out. She was advised to have hCG injections from the next

--- Content provided by‌ FirstRanker.com ---

conception. hCG maintains corpus luteum during:
A) The follicular phase B) The early stages of pregnancy
C) Postmenopausal period D) Menstrual phase
*********
[MBBS 0825]

--- Content provided by‌ FirstRanker.com ---


D
r. . MEDICAL


[MBBS 0825] AUGUST 2025 Sub. Code: 7053

--- Content provided by⁠ FirstRanker.com ---


M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2024-2025)

FIRST PROFESSIONAL ? (CBME)

--- Content provided by FirstRanker.com ---

PAPER I ? PHYSIOLOGY
Q.P. Code: 527053
Time: 20 Minutes

Maximum : 20 Marks

--- Content provided by‌ FirstRanker.com ---

Answer All Questions
Shade the correct answer with Black or Blue ink ball point pen
SET - B
IV. Multiple Choice Questions:

--- Content provided by FirstRanker.com ---



(20 x 1 = 20)
1. 18 years old Anjali, complaints of recurrent painful joint swelling, associated with profuse
menstrual bleeding during her cycles. A diagnosis of Haemophilia was made. Coagulation

--- Content provided by‌ FirstRanker.com ---

abnormality seen in a patient with Haemophilia B disease is
A) Prolonged PT B) Normal PT C) Normal APTT D) Prolonged APTT
2. Which protein blocks the myosin-binding site on actin in resting skeletal muscle?
A) Myosin B) Actin C) Troponin D) Tropomyosin
3. Fast-twitch muscle fibers (Type II) are characterized by:

--- Content provided by​ FirstRanker.com ---

A) High myoglobin content B) Slow contraction velocity
C) High resistance to fatigue D) Anaerobic metabolism
4. Which is true about smooth muscle contraction?
A) Relies exclusively on troponin for calcium binding B) Uses calmodulin instead of troponin
C) Requires somatic motor nerve stimulation D) Is faster than skeletal muscle contraction

--- Content provided by​ FirstRanker.com ---

5. Sarcomere length is decided by the length of
A) A band B) I band C) H band D) M line
6. Which of the following is the correct sequence of layers in the wall of the gastrointestinal
tract from inner to outer?
A) Submucosa Mucosa Muscularis externa Serosa

--- Content provided by‍ FirstRanker.com ---

B) Mucosa Submucosa Muscularis externa Serosa
C) Serosa Muscularis externa Submucosa Mucosa
D) Muscularis externa Mucosa Serosa Submucosa

7. 18 years old Mr. Praveen, A II MBBS students while preparing for his exams complaints

--- Content provided by‍ FirstRanker.com ---

of recurrent epigastric pain. Recurrent he is skipping his regular meals and taking pain
killers for his headache. Which cell is responsible for secreting hydrochloric acid in the
stomach
A) Chief cells B) G cells C) Parietal cells D) Mucous neck cells
8. 40 years old Kumaran, a known alcoholic experienced sudden onset of intractable

--- Content provided by​ FirstRanker.com ---

abdominal pain. His serum amylase and lipase levels are elevated. A diagnosis of acute
pancreatitis was made out which enzyme is secreted in its active form by the pancreas?
A) Trypsin B) Chymotrypsin C) Amylase D) Carboxy peptidase
9. The defecation reflex is initiated primarily by:
A) Entry of food into the stomach B) Distention of the rectum

--- Content provided by‌ FirstRanker.com ---

C) Secretion of bile into the duodenum D) Inhibition of sympathetic tone
... 2 ...

... 2 ...
10. Urea recycling is crucial for:
A) Maintaining acid-base balance B) Driving the countercurrent exchanger

--- Content provided by​ FirstRanker.com ---

C) Facilitating obligatory water loss D) Enhancing medullary osmolarity for urine concentration
11. The kidneys regulate extracellular fluid H+ concentration through all the three
fundamental mechanisms except
A) Direct H secretion B) Bicarbonate excretion
C) Bicarbonate reabsorption D) Production of new bicarbonates

--- Content provided by⁠ FirstRanker.com ---

12. 65 years old male met with road traffic accident and sustained head injuries. Following
recovery he developed a Syndrome of Inappropriate Secretion of Anti diuretic Hormone
(SIADH). Which of the following is true regarding vasopressin (ADH)?
A) It is synthesized in the posterior pituitary
B) It increases water reabsorption via aquaporin-1 channels

--- Content provided by​ FirstRanker.com ---

C) It increases blood volume by acting on the collecting ducts
D) It increases potassium reabsorption
13. The majority of circulating thyroid hormones in blood are:
A) In the free form B) Bound to thyroxine-binding globulin (TBG)
C) Bound to Transthyretin D) Bound to thyroxine-binding prealbumin (TBPA)

--- Content provided by​ FirstRanker.com ---

14. In a case of severe osteoporosis, Calcium supplements with Vitamin-D are prescribed.
Which organ is responsible for the final activation of vitamin D to calcitriol
(1,25-dihydroxycholecalciferol)?
A) Liver B) Kidney C) Intestine D) Skin
15. Capacitation of sperm occurs:

--- Content provided by‍ FirstRanker.com ---

A) In the epididymis B) In the seminal vesicle
C) In the female genital tract D) Inside the seminiferous tubules
16. 28 years old female, a case of recurrent abortions was evaluated and a diagnosis of luteal
phase defect was made out. She was advised to have hCG injections from the next
conception. hCG maintains corpus luteum during:

--- Content provided by⁠ FirstRanker.com ---

A) The follicular phase B) The early stages of pregnancy
C) Postmenopausal period D) Menstrual phase
17. The release of hormones and neurotransmitters is an example of
A) Active Transport B) Vesicular Transport
C) Facilitated Diffusion D) Pinocytocsis

--- Content provided by FirstRanker.com ---

18. The indicator used for the measurement of Plasma volume is
A) Inulin B) Deuterium C) Evans Blue D) Radio-labelled Chromium

19. Resting Membrane Potential of thick Spinal motor neurons
A) -30 mV B) -45 mV C) -90 mV D) Fluctuating

--- Content provided by⁠ FirstRanker.com ---

20. Microcytic Hypochromic Anaemia is a features of
A) Thalassemia B) Acute Blood loss
C) Pernicious anaemia D) Sickle Cell anaemia
*********
[MBBS 0825]

--- Content provided by‌ FirstRanker.com ---


D
r. . MEDICAL


[MBBS 0825] AUGUST 2025 Sub. Code: 7053

--- Content provided by‍ FirstRanker.com ---


M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2024-2025)

FIRST PROFESSIONAL ? (CBME)

--- Content provided by⁠ FirstRanker.com ---

PAPER I ? PHYSIOLOGY
Q.P. Code: 527053
Time: 20 Minutes

Maximum : 20 Marks

--- Content provided by‌ FirstRanker.com ---

Answer All Questions
Shade the correct answer with Black or Blue ink ball point pen
SET - C
IV. Multiple Choice Questions:

--- Content provided by‍ FirstRanker.com ---



(20 x 1 = 20)
1. The kidneys regulate extracellular fluid H+ concentration through all the three
fundamental mechanisms except

--- Content provided by‌ FirstRanker.com ---

A) Direct H secretion B) Bicarbonate excretion
C) Bicarbonate reabsorption D) Production of new bicarbonates
2. 65 years old male met with road traffic accident and sustained head injuries. Following
recovery he developed a Syndrome of Inappropriate Secretion of Anti diuretic Hormone
(SIADH). Which of the following is true regarding vasopressin (ADH)?

--- Content provided by⁠ FirstRanker.com ---

A) It is synthesized in the posterior pituitary
B) It increases water reabsorption via aquaporin-1 channels
C) It increases blood volume by acting on the collecting ducts
D) It increases potassium reabsorption
3. The majority of circulating thyroid hormones in blood are:

--- Content provided by​ FirstRanker.com ---

A) In the free form B) Bound to thyroxine-binding globulin (TBG)
C) Bound to Transthyretin D) Bound to thyroxine-binding prealbumin (TBPA)
4. In a case of severe osteoporosis, Calcium supplements with Vitamin-D are prescribed.
Which organ is responsible for the final activation of vitamin D to calcitriol
(1,25-dihydroxycholecalciferol)?

--- Content provided by​ FirstRanker.com ---

A) Liver B) Kidney C) Intestine D) Skin
5. Capacitation of sperm occurs:
A) In the epididymis B) In the seminal vesicle
C) In the female genital tract D) Inside the seminiferous tubules
6. 28 years old female, a case of recurrent abortions was evaluated and a diagnosis of luteal

--- Content provided by FirstRanker.com ---

phase defect was made out. She was advised to have hCG injections from the next
conception. hCG maintains corpus luteum during:
A) The follicular phase B) The early stages of pregnancy
C) Postmenopausal period D) Menstrual phase
7. The release of hormones and neurotransmitters is an example of

--- Content provided by FirstRanker.com ---

A) Active Transport B) Vesicular Transport
C) Facilitated Diffusion D) Pinocytocsis
8. The indicator used for the measurement of Plasma volume is
A) Inulin B) Deuterium C) Evans Blue D) Radio-labelled Chromium
... 2 ...

--- Content provided by⁠ FirstRanker.com ---



... 2 ...
9. Resting Membrane Potential of thick Spinal motor neurons
A) -30 mV B) -45 mV C) -90 mV D) Fluctuating
10. Microcytic Hypochromic Anaemia is a features of

--- Content provided by FirstRanker.com ---

A) Thalassemia B) Acute Blood loss
C) Pernicious anaemia D) Sickle Cell anaemia
11. 18 years old Anjali, complaints of recurrent painful joint swelling, associated with profuse
menstrual bleeding during her cycles. A diagnosis of Haemophilia was made. Coagulation
abnormality seen in a patient with Haemophilia B disease is

--- Content provided by‍ FirstRanker.com ---

A) Prolonged PT B) Normal PT C) Normal APTT D) Prolonged APTT
12. Which protein blocks the myosin-binding site on actin in resting skeletal muscle?
A) Myosin B) Actin C) Troponin D) Tropomyosin
13. Fast-twitch muscle fibers (Type II) are characterized by:
A) High myoglobin content B) Slow contraction velocity

--- Content provided by‌ FirstRanker.com ---

C) High resistance to fatigue D) Anaerobic metabolism
14. Which is true about smooth muscle contraction?
A) Relies exclusively on troponin for calcium binding B) Uses calmodulin instead of troponin
C) Requires somatic motor nerve stimulation D) Is faster than skeletal muscle contraction
15. Sarcomere length is decided by the length of

--- Content provided by FirstRanker.com ---

A) A band B) I band C) H band D) M line
16. Which of the following is the correct sequence of layers in the wall of the gastrointestinal
tract from inner to outer?
A) Submucosa Mucosa Muscularis externa Serosa
B) Mucosa Submucosa Muscularis externa Serosa

--- Content provided by‍ FirstRanker.com ---

C) Serosa Muscularis externa Submucosa Mucosa
D) Muscularis externa Mucosa Serosa Submucosa

17. 18 years old Mr. Praveen, A II MBBS students while preparing for his exams complaints
of recurrent epigastric pain. Recurrent he is skipping his regular meals and taking pain

--- Content provided by‌ FirstRanker.com ---

killers for his headache. Which cell is responsible for secreting hydrochloric acid in the
stomach
A) Chief cells B) G cells C) Parietal cells D) Mucous neck cells
18. 40 years old Kumaran, a known alcoholic experienced sudden onset of intractable
abdominal pain. His serum amylase and lipase levels are elevated. A diagnosis of acute

--- Content provided by​ FirstRanker.com ---

pancreatitis was made out which enzyme is secreted in its active form by the pancreas?
A) Trypsin B) Chymotrypsin C) Amylase D) Carboxy peptidase
19. The defecation reflex is initiated primarily by:
A) Entry of food into the stomach B) Distention of the rectum
C) Secretion of bile into the duodenum D) Inhibition of sympathetic tone

--- Content provided by​ FirstRanker.com ---

20. Urea recycling is crucial for:
A) Maintaining acid-base balance B) Driving the countercurrent exchanger
C) Facilitating obligatory water loss D) Enhancing medullary osmolarity for urine concentration
*********
[MBBS 0825]

--- Content provided by FirstRanker.com ---


D
r. . MEDICAL


[MBBS 0825] AUGUST 2025 Sub. Code: 7053

--- Content provided by‍ FirstRanker.com ---


M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2024-2025)

FIRST PROFESSIONAL ? (CBME)

--- Content provided by​ FirstRanker.com ---

PAPER I ? PHYSIOLOGY
Q.P. Code: 527053
Time: 20 Minutes

Maximum : 20 Marks

--- Content provided by FirstRanker.com ---

Answer All Questions
Shade the correct answer with Black or Blue ink ball point pen
SET - D
IV. Multiple Choice Questions:

--- Content provided by⁠ FirstRanker.com ---



(20 x 1 = 20)

1. Capacitation of sperm occurs:

--- Content provided by FirstRanker.com ---

A) In the epididymis B) In the seminal vesicle
C) In the female genital tract D) Inside the seminiferous tubules
2. 28 years old female, a case of recurrent abortions was evaluated and a diagnosis of luteal
phase defect was made out. She was advised to have hCG injections from the next
conception. hCG maintains corpus luteum during:

--- Content provided by​ FirstRanker.com ---

A) The follicular phase B) The early stages of pregnancy
C) Postmenopausal period D) Menstrual phase
3. The release of hormones and neurotransmitters is an example of
A) Active Transport B) Vesicular Transport
C) Facilitated Diffusion D) Pinocytocsis

--- Content provided by‍ FirstRanker.com ---

4. The indicator used for the measurement of Plasma volume is
A) Inulin B) Deuterium C) Evans Blue D) Radio-labelled Chromium

5. Resting Membrane Potential of thick Spinal motor neurons
A) -30 mV B) -45 mV C) -90 mV D) Fluctuating

--- Content provided by FirstRanker.com ---

6. Microcytic Hypochromic Anaemia is a features of
A) Thalassemia B) Acute Blood loss
C) Pernicious anaemia D) Sickle Cell anaemia
7. 18 years old Anjali, complaints of recurrent painful joint swelling, associated with profuse
menstrual bleeding during her cycles. A diagnosis of Haemophilia was made. Coagulation

--- Content provided by⁠ FirstRanker.com ---

abnormality seen in a patient with Haemophilia B disease is
A) Prolonged PT B) Normal PT C) Normal APTT D) Prolonged APTT
8. Which protein blocks the myosin-binding site on actin in resting skeletal muscle?
A) Myosin B) Actin C) Troponin D) Tropomyosin
9. Fast-twitch muscle fibers (Type II) are characterized by:

--- Content provided by‍ FirstRanker.com ---

A) High myoglobin content B) Slow contraction velocity
C) High resistance to fatigue D) Anaerobic metabolism
10. Which is true about smooth muscle contraction?
A) Relies exclusively on troponin for calcium binding B) Uses calmodulin instead of troponin
C) Requires somatic motor nerve stimulation D) Is faster than skeletal muscle contraction

--- Content provided by‍ FirstRanker.com ---

... 2 ...


... 2 ...
11. Sarcomere length is decided by the length of
A) A band B) I band C) H band D) M line

--- Content provided by FirstRanker.com ---

12. Which of the following is the correct sequence of layers in the wall of the gastrointestinal
tract from inner to outer?
A) Submucosa Mucosa Muscularis externa Serosa
B) Mucosa Submucosa Muscularis externa Serosa
C) Serosa Muscularis externa Submucosa Mucosa

--- Content provided by‌ FirstRanker.com ---

D) Muscularis externa Mucosa Serosa Submucosa

13. 18 years old Mr. Praveen, A II MBBS students while preparing for his exams complaints
of recurrent epigastric pain. Recurrent he is skipping his regular meals and taking pain
killers for his headache. Which cell is responsible for secreting hydrochloric acid in the

--- Content provided by FirstRanker.com ---

stomach
A) Chief cells B) G cells C) Parietal cells D) Mucous neck cells
14. 40 years old Kumaran, a known alcoholic experienced sudden onset of intractable
abdominal pain. His serum amylase and lipase levels are elevated. A diagnosis of acute
pancreatitis was made out which enzyme is secreted in its active form by the pancreas?

--- Content provided by⁠ FirstRanker.com ---

A) Trypsin B) Chymotrypsin C) Amylase D) Carboxy peptidase
15. The defecation reflex is initiated primarily by:
A) Entry of food into the stomach B) Distention of the rectum
C) Secretion of bile into the duodenum D) Inhibition of sympathetic tone
16. Urea recycling is crucial for:

--- Content provided by​ FirstRanker.com ---

A) Maintaining acid-base balance B) Driving the countercurrent exchanger
C) Facilitating obligatory water loss D) Enhancing medullary osmolarity for urine concentration
17. The kidneys regulate extracellular fluid H+ concentration through all the three
fundamental mechanisms except
A) Direct H secretion B) Bicarbonate excretion

--- Content provided by​ FirstRanker.com ---

C) Bicarbonate reabsorption D) Production of new bicarbonates
18. 65 years old male met with road traffic accident and sustained head injuries. Following
recovery he developed a Syndrome of Inappropriate Secretion of Anti diuretic Hormone
(SIADH). Which of the following is true regarding vasopressin (ADH)?
A) It is synthesized in the posterior pituitary

--- Content provided by‍ FirstRanker.com ---

B) It increases water reabsorption via aquaporin-1 channels
C) It increases blood volume by acting on the collecting ducts
D) It increases potassium reabsorption
19. The majority of circulating thyroid hormones in blood are:
A) In the free form B) Bound to thyroxine-binding globulin (TBG)

--- Content provided by FirstRanker.com ---

C) Bound to Transthyretin D) Bound to thyroxine-binding prealbumin (TBPA)
20. In a case of severe osteoporosis, Calcium supplements with Vitamin-D are prescribed.
Which organ is responsible for the final activation of vitamin D to calcitriol
(1,25-dihydroxycholecalciferol)?
A) Liver B) Kidney C) Intestine D) Skin

--- Content provided by‍ FirstRanker.com ---

*********
[MBBS 0825]