D
r. . MEDICAL
[MBBS 0825] AUGUST 2025 Sub. Code: 7055
(For the candidates admitted from the Academic Year 2024-2025)
FIRST PROFESSIONAL ? (CBME)
PAPER I ? BIOCHEMISTRY
Time: Three hours Maximum : 100 Marks (80 Theory + 20 MCQs)
Answer All Questions
I. Essay:
(1 x 10 = 10)
1. A 8-year-old boy presented with pallor, fatigue and generalized weakness.
H/o having taken sulfa drugs for a bacterial infection present. On examination
a) Which enzyme in deficient in this hemolytic disorder. (1)
b) Brief the steps of the metabolic pathway involved. (4)
c) Discuss the significance of this pathway. (5)
II. Reasoning out short notes :
(2 x 5 = 10)
1. Streptokinase is used in thrombolysis in Acute Myocardial Infarction (AMI).
b) Mention three cardiac biomarkers and their time of onset, peak and fall in
blood levels. (3)
2. Discuss the statement: Carbohydrates are absolutely required for the oxidation
of fats.
(10 x 6 = 60)
1. Enumerate the functions of Copper and brief the disorders associated with
copper.
2. Regulation of Citric acid cycle.
3. Explain Uncoupling of oxidative phosphorylation. Give four examples of
4. A 2 year old child presented with liver enlargement, fasting hypoglycemia,
increased uric acid and lactate levels.
Glucose: 50mg%, Urine positive for ketone bodies.
a) What is the possible diagnosis? Name the enzyme deficient (1+1)
5. Congenital Hyperbilirubinemia.
6. a) List any four causes of Nonalcoholic Fatty liver. (2)
b) Discuss the Metabolism of HDL. (4)
... 2 ...
... 2 ...
7. Several people attending a family gathering suspected to have consumed illicit
liquor, was brought to emergency in seriously ill condition.
a) What poisoning will you suspect in these patients? (1)
b) Discuss how alcohol is metabolized by our body. (4)
8. A vitamin deficiency that can cause methylmalonic aciduria.
Name the vitamin and discuss the role of the vitamin in this condition. (1+5)
9. Define Basal Metabolic Rate. Brief the factors affecting and the measurement of
BMR. (1+3+2)
growth.
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[MBBS 0825]
r. . MEDICAL
[MBBS 0825] AUGUST 2025 Sub. Code: 7055
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M.B.B.S. DEGREE EXAMINATION(For the candidates admitted from the Academic Year 2024-2025)
FIRST PROFESSIONAL ? (CBME)
PAPER I ? BIOCHEMISTRY
--- Content provided by FirstRanker.com ---
Q.P. Code: 527055Time: Three hours Maximum : 100 Marks (80 Theory + 20 MCQs)
Answer All Questions
I. Essay:
--- Content provided by FirstRanker.com ---
(1 x 10 = 10)
1. A 8-year-old boy presented with pallor, fatigue and generalized weakness.
H/o having taken sulfa drugs for a bacterial infection present. On examination
--- Content provided by FirstRanker.com ---
child was anemic, mild jaundice present.a) Which enzyme in deficient in this hemolytic disorder. (1)
b) Brief the steps of the metabolic pathway involved. (4)
c) Discuss the significance of this pathway. (5)
II. Reasoning out short notes :
--- Content provided by FirstRanker.com ---
(2 x 5 = 10)
1. Streptokinase is used in thrombolysis in Acute Myocardial Infarction (AMI).
--- Content provided by FirstRanker.com ---
a) How does it act? (2)b) Mention three cardiac biomarkers and their time of onset, peak and fall in
blood levels. (3)
2. Discuss the statement: Carbohydrates are absolutely required for the oxidation
of fats.
--- Content provided by FirstRanker.com ---
III. Write short notes on:(10 x 6 = 60)
--- Content provided by FirstRanker.com ---
1. Enumerate the functions of Copper and brief the disorders associated with
copper.
2. Regulation of Citric acid cycle.
3. Explain Uncoupling of oxidative phosphorylation. Give four examples of
--- Content provided by FirstRanker.com ---
uncouplers. (4+2)4. A 2 year old child presented with liver enlargement, fasting hypoglycemia,
increased uric acid and lactate levels.
Glucose: 50mg%, Urine positive for ketone bodies.
a) What is the possible diagnosis? Name the enzyme deficient (1+1)
--- Content provided by FirstRanker.com ---
b) Reason out the biochemical basis of these finding. (4)5. Congenital Hyperbilirubinemia.
6. a) List any four causes of Nonalcoholic Fatty liver. (2)
b) Discuss the Metabolism of HDL. (4)
... 2 ...
--- Content provided by FirstRanker.com ---
... 2 ...
7. Several people attending a family gathering suspected to have consumed illicit
liquor, was brought to emergency in seriously ill condition.
a) What poisoning will you suspect in these patients? (1)
b) Discuss how alcohol is metabolized by our body. (4)
--- Content provided by FirstRanker.com ---
c) Name the laboratory findings in Chronic Alcoholism. (1)8. A vitamin deficiency that can cause methylmalonic aciduria.
Name the vitamin and discuss the role of the vitamin in this condition. (1+5)
9. Define Basal Metabolic Rate. Brief the factors affecting and the measurement of
BMR. (1+3+2)
--- Content provided by FirstRanker.com ---
10. Discuss how the commitment to lifelong learning forms part of the physiciangrowth.
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[MBBS 0825]
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