Date: I1
7-
M 0
B 2
B-2

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S 02
Bi 4
ochemistry Paper 1
0224E 657
Time: 3 hours

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Max Marks: 100
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each

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section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Structured Long Question

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(Any 1 out of 2)
(1x10=10)
a) Describe the pathway of Glycolysis.
Explain its energetics. Write a note on
Rapoport Luebering shunt.

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(6+2+2)

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b) Explain the heme synthesis. Add note on
thalassemia
(6+4)
2. Case based scenario/Applied

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short note (Any 2 out of 3)
(2x6=12)
a) A premature born baby with
yellow coloration of the eyes showed 11
mg/dl of total serum bilirubin, most of it

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being unconjugated type. The baby was kept
under ultraviolet light lamp. The serum
bilirubin level return to normal after 9 days.:
(1+14+2+2) a. What is the probable
diagnosis? b. What is the reason behind the

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transient increase in serum bilirubin? c.
What is the basis of UV light therapy? d.
What are the consequences if the serum
bilirubin levels increase beyond 20mg/dl ?
(10)

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b) A32 years old heavy smoker
developed sudden crushing chest pain. He
was admitted to the casualty department
Myocardial infarction was confirmed.
(1+2+1+2) a. Is there any relationship

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between smoking and myocardial infarction?
b. What are the preventive measures against
the development of heart disease? c. Name
the lipoprotein that has protective effect
against the development of MI. d. Write the

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cardiac markers.
(12)
c) A 12 years old girl was admitted to
hospital. Her mother mentioned that her
daughter had been losing weight and had

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polyuria. The Doctor noticed a fruity breath.
On admission the followin biochemical
parameters of urine and blood were
obtained. GI+2+2 Urine pH 5.4 Urine
glucose (+++) Blood glucose - 460 mg/dl

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Urine ketone positive. a, Which type of
diabetes she is suffering from? b. What is
the cause of fruity breath? c. What are the
causes of weight loss? S d. Name the ketone
bodies.

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3. Write short notes (Any 3 out
of 4)
(3x6=18)

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a) Biomedical importance of
heteropolysaccharide

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b) Significance and disorders of HMP shunt
pathway
c) Explain the chemiosmotic theory of
oxidative phosphorylation
d) Describe the importance of effective

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communication in medical field
(18)
4. Answer only in 2-3 sentences
(Any 5 out of 6)
(2x5 =10)

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a) What are uncopulers. Give examples
b) Creatinine clearance
c) What are Bence Jones protein
d) Adverse effect of trans fatty acids on
health

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e) Name two lysosomal disorders

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f) Diagnostic tests for sickle cell anemia pe
(10)
Section 2
5. Structured Long Question

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(Any lout of 2)
(1x10 =10)
a) Describe the diagnostic role of
isoenzymes in any two diseases with
example. Therapeutic applications of

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enzymes
(6+4)
b) Describe cholesterol biosynthesis with its
regulation. Add note on atherosclerosis
(743)

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6. Write short notes (Any 2
out of 3)
(2x6=12)
a) Factors affecting enzyme activity
b) Different types of transport systems

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across cell membrane.
c) Types and function of Immunoglobulin
(12)

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7. Write short notes (Any 3 out
of 4)

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(3x6=18)
a) Essential fatty acids
b) Detoxification by phase I reactions
c) Tumor markers
d) Hormonal regulation of water balance

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(18)
8. answers only in 2-3
sentences (Any 5 out of 6)
(2x5=10)
a) Enumerate the causes of

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respiratory acidosis
b) Define phospholipids. Give examples
c) Define isoenzymes with suitable examples
d) Define coenzyme.Write coenzymes of
niacin

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e) Enumerate the causes of fatty liver
f) Applications of chromatography =
(10)

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