0818E304
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Date: 03-08-2018
Time: 3 hours

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Max Marks: 50
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each

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section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Write short notes on the following

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a) Gout and LeschNyhan
(10)
syndrome(A. 548)(C. 394)

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b) Night blindness and role of vitamin
A

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c) Phenylketonuria(A. 292) (C. 351)
2. Write Short notes of (any three) (9)
a) Point mutations
b) Structure and functions of t RNA(A.
578)(C. 81)

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c) Western blotting technique
d) Applications of Recombinant DNA
technology(A. 600) (C. 579)
e) Inhibitors of protein synthesis(A.
584) (C.558)

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3. Discuss Any TWO
(6)
a) Protein energy malnutrition (PEM)
(A. 516) (C. 516)
b) Role of fibre in the body(A. 514) (C.

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508)
c) Biochemical changes in well fed
state

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Section 2
4. Write Short notes on (any two) (10)

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a) Biochemical functions of copper
and Zinc
b) Explain how ammonia is disposed
via glutamate, glutamine and urea
c) Biologically important peptides

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5. Write Short notes on (any two) (9)
a) Biochemical role of vitamin B12(A.
491) (C. 153)
b) Functions of biologically important
nucleotides(A.541)

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c) Salvage pathway of purines(A. 546)
(C. 391)
d) Antioxidant vitamins(A. 429) (C.
659)
e) Degradation of pyrimidines(A. 551)

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(C. 400)

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6. Case report: A three year old child
was brought to the paediatric OPD with
complaints of slow growth and severe
pain in bones. He was pale, had bow

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legs, knock knees, pigeon chest and
swelling of the costochondrial junctions.
His biochemical investigations showed
Serum calcium 7.6 mgs% (Normal 9-11
mg%) Serum Inorg.Phos. 2.6 mgs%

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(normal 4-6 mgs%) and serum Alkaline
Phosphate 720 U/L(normal 26-91 U/L).
Answer the following questions (any
six):
(6)

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1. What is the likely diagnosis?
2. Which other biochemical test will help
to ascertain the diagnosis?
3. What is normal Ca:P ratio?
4. Describe the calcium regulation.

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5. Give two factors inhibiting calcium
absorption
6. Suggest measures to correct the
above disorder.
7. Write any two causes of hypocalcemia

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8. Write any two causes of increased
serum alkaline phosphate level.

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Document Outline

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