0819E373
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours
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Max Marks: 1001. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.
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4. Draw diagrams wherever necessary.5. Write legibly.
Section 1
1.Answer any one
(10)
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a) What are the irreversible steps ofa) What are the irreversible steps of
glycolysis and how they are circumvented
in gluconeogenesis? Explain the importance
of key enzymes of gluconeogenesis in the
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metabolism of lactate. How the process ofgluconeogenesis is regulated?
b) What are the different types of
haemoglobinopathies? Write about the
biochemical basis of haemoglobinopathies
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and there clinical relevance.2.Answer any two(case based
scenario/applied short notes)
(12)
a) A boy aged 9 years came with his mother
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with the complaints of bloating abdomen,passing of loose clay coloured, frothy, foul
smelling stool. His stool fat analysis
showed presence of monoacyl glycerol and
diacyl glycerol. (a) What is your diagnosis?
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(b) Which biochemical tests you willperform to confirm the diagnosis?(c)
Mention the role of bile salt in digestion.
b) What are the different types of
immunoglobulins? Write the structure and
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function of each.c) What are the different components of
electron transport chain? Briefly describe
chemiosmotic theory.
3.Write short notes (answer any three)
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(18)a) What is HMP shunt pathway?
Describe how it is important in maintaining
the integrity of erythrocyte.
b) What do you understand by
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mutarotation? Describe it with example.c) Write briefly about physiological
jaundice in new born?
d) What are the four types of doctor patient
relationships? Write the factors affecting
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doctor patient relationship.4.Answer in 2-3 lines (give biochemical
justification) five out of six
(10)
a) Sickle cell anaemia gives protection
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against malaria.b) Ingestion of large amount of fructose
potentiates hyperuricaemia.
c) AST and LDH are raised in prehepatic
jaundice.
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d) Creatinine clearance is better than ureaclearance.
e) Cori's cycle is incomplete in Von
Gierke's disease.
f) Trans fatty acids are injurious to health.
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Section 2
5.Answer any one
(10)
a) What is the normal pH of blood? What
are the different mechanisms of blood pH
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regulation? Describe the renal mechanismof pH regulation.
b) Write the steps of synthesis of
cholesterol? How the synthesis is
regulated? Write a note on normal lipid
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profile.6.Answer any two (case based
scenario/applied short notes)
(12)
a) Role of radioisotope in medicine.
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b) Write a note on allosteric enzymes withexample.
c) Cyt P 450.
7.Write short notes (answer any three)
(18)
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a) RTPCR.b) Suicide enzyme inhibition
c) Regulation of Ketogenesis
d) Tumour suppressor genes
8.Answer in 2-3 lines (give biochemical
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justification) five out of six(10)
a) Importance of HDL in cholesterol
transport.
b) Anion gap.
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c) Oral rehydration therapy.d) Difference between INSULIN and
INULIN.
e) Causes of fatty LIVER.
f) Marine Fish oil is Cardioprotective.
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